Tissue clearing and its applications in neuroscience
State-of-the-art tissue-clearing methods provide subcellular-level optical access to intact
tissues from individual organs and even to some entire mammals. When combined with light …
tissues from individual organs and even to some entire mammals. When combined with light …
Polycystic ovary syndrome: pathophysiology, presentation, and treatment with emphasis on adolescent girls
SF Witchel, SE Oberfield, AS Peña - Journal of the Endocrine …, 2019 - academic.oup.com
Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by
hyperandrogenism and chronic anovulation. Depending on diagnostic criteria, 6% to 20% of …
hyperandrogenism and chronic anovulation. Depending on diagnostic criteria, 6% to 20% of …
A roadmap for the human developmental cell atlas
Abstract The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human
Cell Atlas, aims to create a comprehensive reference map of cells during development. This …
Cell Atlas, aims to create a comprehensive reference map of cells during development. This …
Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood
Polycystic ovary syndrome (PCOS) is the main cause of female infertility worldwide and
corresponds with a high degree of comorbidities and economic burden. How PCOS is …
corresponds with a high degree of comorbidities and economic burden. How PCOS is …
Clinical management of congenital hypogonadotropic hypogonadism
The initiation and maintenance of reproductive capacity in humans is dependent on pulsatile
secretion of the hypothalamic hormone GnRH. Congenital hypogonadotropic hypogonadism …
secretion of the hypothalamic hormone GnRH. Congenital hypogonadotropic hypogonadism …
[HTML][HTML] Tridimensional visualization and analysis of early human development
M Belle, D Godefroy, G Couly, SA Malone, F Collier… - Cell, 2017 - cell.com
Generating a precise cellular and molecular cartography of the human embryo is essential
to our understanding of the mechanisms of organogenesis in normal and pathological …
to our understanding of the mechanisms of organogenesis in normal and pathological …
A GnRH neuronal population in the olfactory bulb translates socially relevant odors into reproductive behavior in male mice
L Decoster, S Trova, S Zucca, J Bulk, A Gouveia… - Nature …, 2024 - nature.com
Hypothalamic gonadotropin-releasing hormone (GnRH) neurons regulate fertility and
integrate hormonal status with environmental cues to ensure reproductive success. Here we …
integrate hormonal status with environmental cues to ensure reproductive success. Here we …
Genetics of congenital hypogonadotropic hypogonadism: peculiarities and phenotype of an oligogenic disease
B Cangiano, DS Swee, R Quinton, M Bonomi - Human genetics, 2021 - Springer
A genetic basis of congenital isolated hypogonadotropic hypogonadism (CHH) can be
defined in almost 50% of cases, albeit not necessarily the complete genetic basis. Next …
defined in almost 50% of cases, albeit not necessarily the complete genetic basis. Next …
Tissue clearing to examine tumour complexity in three dimensions
The visualization of whole organs and organisms through tissue clearing and fluorescence
volumetric imaging has revolutionized the way we look at biological samples. Its application …
volumetric imaging has revolutionized the way we look at biological samples. Its application …
GnRH replacement rescues cognition in Down syndrome
M Manfredi-Lozano, V Leysen, M Adamo, I Paiva… - Science, 2022 - science.org
At the present time, no viable treatment exists for cognitive and olfactory deficits in Down
syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive …
syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive …