Iron deficiency is one of the leading contributors to the global burden of disease, and
particularly affects children, premenopausal women, and people in low-income and middle …

Iron is essential for many biological functions and iron deficiency and overload have major
health implications. We performed a meta-analysis of three genome-wide association …

Although plasma proteins have important roles in biological processes and are the direct
targets of many drugs, the genetic factors that control inter-individual variation in plasma …

Aging is a predominant risk factor for several chronic diseases that limit healthspan.
Mechanisms of aging are thus increasingly recognized as potential therapeutic targets …

Garrod's concept of 'chemical individuality'has contributed to comprehension of the
molecular origins of human diseases. Untargeted high-throughput metabolomic …

The human proteome is a major source of therapeutic targets. Recent genetic association
analyses of the plasma proteome enable systematic evaluation of the causal consequences …

Stroke is the second leading cause of death with substantial unmet therapeutic needs. To
identify potential stroke therapeutic targets, we estimate the causal effects of 308 plasma …

Identifying genetic variants associated with circulating protein concentrations (protein
quantitative trait loci; pQTLs) and integrating them with variants from genome-wide …

In cross-platform analyses of 174 metabolites, we identify 499 associations (P< 4.9× 10− 10)
characterized by pleiotropy, allelic heterogeneity, large and nonlinear effects and …

Peripheral artery disease (PAD) is a leading cause of cardiovascular morbidity and mortality;
however, the extent to which genetic factors increase risk for PAD is largely unknown. Using …