Methane, as natural gas or biogas, is the least expensive source of carbon for (bio) chemical
synthesis. Scalable biological upgrading of this simple alkane to chemicals and fuels can …

Because they mainly do not involve chemical changes, membrane transporters have been a
Cinderella subject in the biotechnology of small molecule production, but this is a serious …

The tumor milieu consists of numerous cell types each existing in a different environment.
However, a characterization of metabolic heterogeneity at single-cell resolution is not …

During aerobic growth on glucose, Escherichia coli excretes acetate, a mechanism called
“overflow metabolism.” At high concentrations, the secreted acetate inhibits growth. Several …

Introduction The human genome-scale metabolic reconstruction details all known metabolic
reactions occurring in humans, and thereby holds substantial promise for studying complex …

Constraint-based models of metabolism are a widely used framework for predicting flux
distributions in genome-scale biochemical networks. The number of published methods for …

The metabolic heterogeneity and metabolic interplay between cells are known as significant
contributors to disease treatment resistance. However, with the lack of a mature high …

Cancer cells have fundamentally altered cellular metabolism that is associated with their
tumorigenicity and malignancy. In addition to the widely studied Warburg effect, several new …

Background Systems biology projects and omics technologies have led to a growing
number of biochemical pathway models and reconstructions. However, the majority of these …

Metabolic reprogramming is a general feature of cancer cells. Regrettably, the
comprehensive quantification of metabolites in biological specimens does not promptly …