Antimicrobial resistance: a concise update
CS Ho, CTH Wong, TT Aung… - The Lancet …, 2024 - thelancet.com
Antimicrobial resistance (AMR) is a serious threat to global public health, with approximately
5 million deaths associated with bacterial AMR in 2019. Tackling AMR requires a …
5 million deaths associated with bacterial AMR in 2019. Tackling AMR requires a …
Urinary tract infections: pathogenesis, host susceptibility and emerging therapeutics
MR Timm, SK Russell, SJ Hultgren - Nature Reviews Microbiology, 2024 - nature.com
Urinary tract infections (UTIs), which include any infection of the urethra, bladder or kidneys,
account for an estimated 400 million infections and billions of dollars in health-care …
account for an estimated 400 million infections and billions of dollars in health-care …
A swapped genetic code prevents viral infections and gene transfer
Engineering the genetic code of an organism has been proposed to provide a firewall from
natural ecosystems by preventing viral infections and gene transfer,,,,–. However, numerous …
natural ecosystems by preventing viral infections and gene transfer,,,,–. However, numerous …
Multistep diversification in spatiotemporal bacterial-phage coevolution
The evolutionary arms race between phages and bacteria, where bacteria evolve resistance
to phages and phages retaliate with resistance-countering mutations, is a major driving force …
to phages and phages retaliate with resistance-countering mutations, is a major driving force …
Improved bacterial recombineering by parallelized protein discovery
Exploiting bacteriophage-derived homologous recombination processes has enabled
precise, multiplex editing of microbial genomes and the construction of billions of …
precise, multiplex editing of microbial genomes and the construction of billions of …
Recombineering and MAGE
Recombination-mediated genetic engineering, also known as recombineering, is the
genomic incorporation of homologous single-stranded or double-stranded DNA into …
genomic incorporation of homologous single-stranded or double-stranded DNA into …
Towards next-generation cell factories by rational genome-scale engineering
Metabolic engineering holds the promise to transform the chemical industry and to support
the transition into a circular bioeconomy, by engineering cellular biocatalysts that efficiently …
the transition into a circular bioeconomy, by engineering cellular biocatalysts that efficiently …
Gepotidacin: a novel, oral,'first-in-class' triazaacenaphthylene antibiotic for the treatment of uncomplicated urinary tract infections and urogenital gonorrhoea
RR Watkins, D Thapaliya… - Journal of …, 2023 - academic.oup.com
The ongoing spread of antimicrobial resistance has made the treatment of uncomplicated
urinary tract infections (UTIs) and urogenital gonorrhoea increasingly difficult. New oral …
urinary tract infections (UTIs) and urogenital gonorrhoea increasingly difficult. New oral …
[HTML][HTML] Evaluating the innovative potential of the global antibacterial pipeline
U Theuretzbacher - Clinical Microbiology and Infection, 2023 - Elsevier
Background Resistance burden varies widely among WHO regions, and the potential impact
of new antibiotics differs in addressing the WHO's critical priority pathogens' resistance …
of new antibiotics differs in addressing the WHO's critical priority pathogens' resistance …
Development and selection of low-level multi-drug resistance over an extended range of sub-inhibitory ciprofloxacin concentrations in Escherichia coli
C Ching, MH Zaman - Scientific reports, 2020 - nature.com
To better combat bacterial antibiotic resistance, a growing global health threat, it is
imperative to understand its drivers and underlying biological mechanisms. One potential …
imperative to understand its drivers and underlying biological mechanisms. One potential …