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Alkaline phosphatase: a reliable endogenous partner for drug delivery and diagnostics
Since the 1960s the membrane‐bound enzyme alkaline phosphatase (ALP) has been
utilized in drug delivery. As it cleaves phosphate substructures from drugs, auxiliary agents …
utilized in drug delivery. As it cleaves phosphate substructures from drugs, auxiliary agents …
Design, synthesis, spectroscopic characterizations, in vitro pancreatic lipase as well as tyrosinase inhibition evaluations and in silico analysis of novel aryl sulfonate …
One of the primary purposes of this study is to synthesize new aryl sulfonate-naphthalene
hybrid structures possessing divergent electron-withdrawing and electron-releasing …
hybrid structures possessing divergent electron-withdrawing and electron-releasing …
Monitoring protein conformational changes using fluorescent nanoantennas
Understanding the relationship between protein structural dynamics and function is crucial
for both basic research and biotechnology. However, methods for studying the fast dynamics …
for both basic research and biotechnology. However, methods for studying the fast dynamics …
Semicarbazones, thiosemicarbazone, thiazole and oxazole analogues as monoamine oxidase inhibitors: Synthesis, characterization, biological evaluation, molecular …
A series of semicarbazone, thiosemicarbazone, thiazole, and oxazole derivatives were
designed, synthesized, and examined for monoamine oxidase inhibition using two isoforms …
designed, synthesized, and examined for monoamine oxidase inhibition using two isoforms …
Effect of the dichloro-substitution on antiproliferative activity of phthalimide-thiazole derivatives. Rational design, synthesis, elastase, caspase 3/7, and EGFR tyrosine …
B Donarska, M Świtalska, W Płaziński, J Wietrzyk… - Bioorganic …, 2021 - Elsevier
Phthalimide derivatives are a promising group of anticancer drugs, while aminothiazoles
have great potential as elastase inhibitors. In these context fourteen phthalimido-thiazoles …
have great potential as elastase inhibitors. In these context fourteen phthalimido-thiazoles …
Exploring thiazole-linked thioureas using alkaline phosphatase assay, biochemical evaluation, computational analysis and structure–activity relationship (SAR) …
This study was carried out to identify the synthesis of a new group of thiazole-linked
thioureas with aromatic and aliphatic side chains (4a–k) using a one-pot three-component …
thioureas with aromatic and aliphatic side chains (4a–k) using a one-pot three-component …
Novel 1, 3, 4-oxadiazole compounds inhibit the tyrosinase and melanin level: Synthesis, in-vitro, and in-silico studies
In this research work, we have designed and synthesized some biologically useful of 1, 3, 4-
Oxadiazoles. The structural interpretation of the synthesized compounds has been validated …
Oxadiazoles. The structural interpretation of the synthesized compounds has been validated …
Structural, antioxidant, antiproliferative and in‒silico study of pyridine-based hydrazonyl‒selenazoles and their sulphur isosteres
JB Araškov, M Nikolić, S Armaković… - Journal of molecular …, 2021 - Elsevier
To evaluate the impact of chalcogen atom type, we performed a comparative study of
antioxidant capacity and antiproliferative activity of a focused library of three pyridine-based …
antioxidant capacity and antiproliferative activity of a focused library of three pyridine-based …
Synthesis, single crystal structure determinations, Hirshfeld surface analysis, crystal voids, interaction energies, and density functional theory studies of functionalized …
The current research offers synthesis, single crystal X-ray structure determinations, Hirshfeld
surface analysis, interaction energies, and density functional theory calculations of …
surface analysis, interaction energies, and density functional theory calculations of …
Exploring amantadine derivatives as urease inhibitors: Molecular docking and structure–activity relationship (SAR) studies
This article describes the design and synthesis of a series of novel amantadine-thiourea
conjugates (3a–j) as Jack bean urease inhibitors. The synthesized hybrids were assayed for …
conjugates (3a–j) as Jack bean urease inhibitors. The synthesized hybrids were assayed for …