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Targeting fibrosis: mechanisms and clinical trials
M Zhao, L Wang, M Wang, S Zhou, Y Lu… - Signal transduction and …, 2022 - nature.com
Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …
dysregulated wound and connective tissue repair response. Multiple organs can develop …
Fibrosis: from mechanisms to medicines
Fibrosis can affect any organ and is responsible for up to 45% of all deaths in the
industrialized world. It has long been thought to be relentlessly progressive and irreversible …
industrialized world. It has long been thought to be relentlessly progressive and irreversible …
Realveolarization with inhalable mucus-penetrating lipid nanoparticles for the treatment of pulmonary fibrosis in mice
Y Wang, J Zhang, Y Liu, X Yue, K Han, Z Kong… - Science …, 2024 - science.org
The stemness loss–associated dysregeneration of impaired alveolar type 2 epithelial (AT2)
cells abolishes the reversible therapy of idiopathic pulmonary fibrosis (IPF). We here report …
cells abolishes the reversible therapy of idiopathic pulmonary fibrosis (IPF). We here report …
Mesenchymal stem cells and their microenvironment
Mesenchymal stem cells (MSCs), coming from a wide range of sources, have multi-
directional differentiation ability. MSCs play vital roles in immunomodulation, hematopoiesis …
directional differentiation ability. MSCs play vital roles in immunomodulation, hematopoiesis …
[HTML][HTML] Structure analysis of the receptor binding of 2019-nCoV
Y Chen, Y Guo, Y Pan, ZJ Zhao - Biochemical and biophysical research …, 2020 - Elsevier
nCoV is a newly identified coronavirus with high similarity to SARS-CoV. We performed a
structural analysis of the receptor binding domain (RBD) of spike glycoprotein responsible …
structural analysis of the receptor binding domain (RBD) of spike glycoprotein responsible …
Regulation of immune responses by the airway epithelial cell landscape
The community of cells lining our airways plays a collaborative role in the preservation of
immune homeostasis in the lung and provides protection from the pathogens and pollutants …
immune homeostasis in the lung and provides protection from the pathogens and pollutants …
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis
The cell type specific sequences of transcriptional programs during lung regeneration have
remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model …
remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model …
Idiopathic pulmonary fibrosis: Disease mechanisms and drug development
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause
characterized by relentless scarring of the lung parenchyma leading to reduced quality of life …
characterized by relentless scarring of the lung parenchyma leading to reduced quality of life …
The impact of sex on gene expression across human tissues
INTRODUCTION Many complex human phenotypes, including diseases, exhibit sex-
differentiated characteristics. These sex differences have been variously attributed to …
differentiated characteristics. These sex differences have been variously attributed to …
Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis
We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung
disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 …
disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 …