Why not try harder? Computational approach to motivation deficits in neuro-psychiatric diseases
Motivation deficits, such as apathy, are pervasive in both neurological and psychiatric
diseases. Even when they are not the core symptom, they reduce quality of life, compromise …
diseases. Even when they are not the core symptom, they reduce quality of life, compromise …
Cognition, function, and disability in patients with schizophrenia: a review of longitudinal studies
This paper aims to review longitudinal studies assessing the impact of cognition on function
in patients with schizophrenia. PubMed and Scholars Portal were searched using search …
in patients with schizophrenia. PubMed and Scholars Portal were searched using search …
The influence of illness‐related variables, personal resources and context‐related factors on real‐life functioning of people with schizophrenia
In people suffering from schizophrenia, major areas of everyday life are impaired, including
independent living, productive activities and social relationships. Enhanced understanding …
independent living, productive activities and social relationships. Enhanced understanding …
Cerebral organoids reveal early cortical maldevelopment in schizophrenia—computational anatomy and genomics, role of FGFR1
EK Stachowiak, CA Benson, ST Narla, A Dimitri… - Translational …, 2017 - nature.com
Studies of induced pluripotent stem cells (iPSCs) from schizophrenia patients and control
individuals revealed that the disorder is programmed at the preneuronal stage, involves a …
individuals revealed that the disorder is programmed at the preneuronal stage, involves a …
Motivational and neurocognitive deficits are central to the prediction of longitudinal functional outcome in schizophrenia
Objective Functional impairment is characteristic of most individuals with schizophrenia;
however, the key variables that undermine community functioning are not well understood …
however, the key variables that undermine community functioning are not well understood …
Impact of primary negative symptoms on functional outcomes in schizophrenia
ObjectiveNegative symptoms are known to undermine functional outcomes in people with
schizophrenia; however, most studies have not accounted for whether these symptoms were …
schizophrenia; however, most studies have not accounted for whether these symptoms were …
Incentive motivation deficits in schizophrenia reflect effort computation impairments during cost-benefit decision-making
Background Motivational impairments are a core feature of schizophrenia and although
there are numerous reports studying this feature using clinical rating scales, objective …
there are numerous reports studying this feature using clinical rating scales, objective …
Motivational deficits in early schizophrenia: prevalent, persistent, and key determinants of functional outcome
Negative symptoms, in particular motivational deficits, are reported as impediments to
functional recovery in patients with schizophrenia. This study examined the prevalence of …
functional recovery in patients with schizophrenia. This study examined the prevalence of …
Categorical and dimensional approaches to negative symptoms of schizophrenia: focus on long-term stability and functional outcome
Negative symptoms of schizophrenia represent a heterogeneous psychopathological
domain. Both categorical and dimensional approaches have been proposed to reduce …
domain. Both categorical and dimensional approaches have been proposed to reduce …
Impairments in episodic future thinking for positive events and anticipatory pleasure in major depression
Background Characteristic of the cardinal symptom of anhedonia, people with clinical
depression report lower levels of anticipatory pleasure. However, the psychological …
depression report lower levels of anticipatory pleasure. However, the psychological …