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Toxicity testing in the 21st century: progress in the past decade and future perspectives
D Krewski, ME Andersen, MG Tyshenko… - Archives of …, 2020 - Springer
Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …
based on expanded application of high-throughput in vitro screening and in silico methods …
Integrating tools for non-targeted analysis research and chemical safety evaluations at the US EPA
Tens-of-thousands of chemicals are registered in the US for use in countless processes and
products. Recent evidence suggests that many of these chemicals are measureable in …
products. Recent evidence suggests that many of these chemicals are measureable in …
The CompTox Chemistry Dashboard: a community data resource for environmental chemistry
Despite an abundance of online databases providing access to chemical data, there is
increasing demand for high-quality, structure-curated, open data to meet the various needs …
increasing demand for high-quality, structure-curated, open data to meet the various needs …
The Chemical and Products Database, a resource for exposure-relevant data on chemicals in consumer products
Quantitative data on product chemical composition is a necessary parameter for
characterizing near-field exposure. This data set comprises reported and predicted …
characterizing near-field exposure. This data set comprises reported and predicted …
Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing
We previously integrated dosimetry and exposure with high-throughput screening (HTS) to
enhance the utility of ToxCast HTS data by translating in vitro bioactivity concentrations to …
enhance the utility of ToxCast HTS data by translating in vitro bioactivity concentrations to …
High throughput heuristics for prioritizing human exposure to environmental chemicals
JF Wambaugh, A Wang, KL Dionisio… - … science & technology, 2014 - ACS Publications
The risk posed to human health by any of the thousands of untested anthropogenic
chemicals in our environment is a function of both the hazard presented by the chemical and …
chemicals in our environment is a function of both the hazard presented by the chemical and …
Suspect screening analysis of chemicals in consumer products
KA Phillips, A Yau, KA Favela, KK Isaacs… - … science & technology, 2018 - ACS Publications
A two-dimensional gas chromatography-time-of-flight/mass spectrometry (GC× GC-TOF/MS)
suspect screening analysis method was used to rapidly characterize chemicals in 100 …
suspect screening analysis method was used to rapidly characterize chemicals in 100 …
Household dust as a repository of chemical accumulation: new insights from a comprehensive high-resolution mass spectrometric study
C Moschet, T Anumol, BM Lew… - … science & technology, 2018 - ACS Publications
Chemical exposure in household dust poses potential risks to human health but has been
studied incompletely thus far. Most analytical studies have focused on one or several …
studied incompletely thus far. Most analytical studies have focused on one or several …
SHEDS-HT: an integrated probabilistic exposure model for prioritizing exposures to chemicals with near-field and dietary sources
United States Environmental Protection Agency (USEPA) researchers are develo** a
strategy for high-throughput (HT) exposure-based prioritization of chemicals under the …
strategy for high-throughput (HT) exposure-based prioritization of chemicals under the …
[HTML][HTML] Exploring consumer exposure pathways and patterns of use for chemicals in the environment
Humans are exposed to thousands of chemicals in the workplace, home, and via air, water,
food, and soil. A major challenge in estimating chemical exposures is to understand which …
food, and soil. A major challenge in estimating chemical exposures is to understand which …