Toxicity testing in the 21st century: progress in the past decade and future perspectives

D Krewski, ME Andersen, MG Tyshenko… - Archives of …, 2020 - Springer
Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …

Integrating tools for non-targeted analysis research and chemical safety evaluations at the US EPA

JR Sobus, JF Wambaugh, KK Isaacs… - Journal of exposure …, 2018 - nature.com
Tens-of-thousands of chemicals are registered in the US for use in countless processes and
products. Recent evidence suggests that many of these chemicals are measureable in …

The CompTox Chemistry Dashboard: a community data resource for environmental chemistry

AJ Williams, CM Grulke, J Edwards… - Journal of …, 2017 - Springer
Despite an abundance of online databases providing access to chemical data, there is
increasing demand for high-quality, structure-curated, open data to meet the various needs …

The Chemical and Products Database, a resource for exposure-relevant data on chemicals in consumer products

KL Dionisio, K Phillips, PS Price, CM Grulke, A Williams… - Scientific data, 2018 - nature.com
Quantitative data on product chemical composition is a necessary parameter for
characterizing near-field exposure. This data set comprises reported and predicted …

Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing

BA Wetmore, JF Wambaugh, B Allen… - Toxicological …, 2015 - academic.oup.com
We previously integrated dosimetry and exposure with high-throughput screening (HTS) to
enhance the utility of ToxCast HTS data by translating in vitro bioactivity concentrations to …

High throughput heuristics for prioritizing human exposure to environmental chemicals

JF Wambaugh, A Wang, KL Dionisio… - … science & technology, 2014 - ACS Publications
The risk posed to human health by any of the thousands of untested anthropogenic
chemicals in our environment is a function of both the hazard presented by the chemical and …

Suspect screening analysis of chemicals in consumer products

KA Phillips, A Yau, KA Favela, KK Isaacs… - … science & technology, 2018 - ACS Publications
A two-dimensional gas chromatography-time-of-flight/mass spectrometry (GC× GC-TOF/MS)
suspect screening analysis method was used to rapidly characterize chemicals in 100 …

Household dust as a repository of chemical accumulation: new insights from a comprehensive high-resolution mass spectrometric study

C Moschet, T Anumol, BM Lew… - … science & technology, 2018 - ACS Publications
Chemical exposure in household dust poses potential risks to human health but has been
studied incompletely thus far. Most analytical studies have focused on one or several …

SHEDS-HT: an integrated probabilistic exposure model for prioritizing exposures to chemicals with near-field and dietary sources

KK Isaacs, WG Glen, P Egeghy… - … science & technology, 2014 - ACS Publications
United States Environmental Protection Agency (USEPA) researchers are develo** a
strategy for high-throughput (HT) exposure-based prioritization of chemicals under the …

[HTML][HTML] Exploring consumer exposure pathways and patterns of use for chemicals in the environment

KL Dionisio, AM Frame, MR Goldsmith, JF Wambaugh… - Toxicology reports, 2015 - Elsevier
Humans are exposed to thousands of chemicals in the workplace, home, and via air, water,
food, and soil. A major challenge in estimating chemical exposures is to understand which …