Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

Abstract Machine learning provides researchers a unique opportunity to make metabolic
engineering more predictable. In this review, we offer an introduction to this discipline in …

For over 10 years, ModelSEED has been a primary resource for the construction of draft
genome-scale metabolic models based on annotated microbial or plant genomes. Now …

Metabolic engineering aims to develop efficient cell factories by rewiring cellular
metabolism. As one of the most commonly used cell factories, Saccharomyces cerevisiae …

New synthetic biology capabilities hold the promise of dramatically improving our ability to
engineer biological systems. However, a fundamental hurdle in realizing this potential is our …

Metabolism is highly complex and involves thousands of different connected reactions; it is
therefore necessary to use mathematical models for holistic studies. The use of …

Highlights•Genomatica has developed a commercial bioprocess for the production of 1, 4-
butanediol from dextrose.•A systems biology approach enabled rapid identification and …

Communities of microorganisms (microbiota) are present in all habitats on Earth and are
relevant for agriculture, health, and climate. Deciphering the mechanisms that determine …

Kinetic models of metabolism at a genome scale that faithfully recapitulate the effect of
multiple genetic interventions would be transformative in our ability to reliably design novel …

An increasing number of industrial bioprocesses capitalize on living cells by using them as
cell factories that convert sugars into chemicals. These processes range from the production …