Is spliced-leader (SL) trans-splicing an ancestral eukaryotic characteristic that has been lost
in multiple lineages, or did it arise independently in the various phyla in which it occurs …

Trans‐splicing is the joining together of portions of two separate pre‐mRNA molecules. The
two distinct categories of spliceosomal trans‐splicing are genic trans‐splicing, which joins …

Schistosomiasis is one of the most prevalent parasitic diseases, affecting millions of people
in develo** countries. Amongst the human-infective species, Schistosoma mansoni is also …

We have developed RNA molecules capable of effecting spliceosome-mediated RNA trans-
splicing reactions with a target messenger RNA precursor (pre-mRNA). Targeted trans …

The PHD fingers of the human MLL and Drosophila trx proteins have strong amino acid
sequence conservation but their function is unknown. We have determined that these fingers …

Members of a new molecular family of bacterial nonspecific acid phosphatases (NSAPs),
indicated as class C, were found to share significant sequence similarities to bacterial class …

Background The cestode Echinococcus granulosus-the agent of cystic echinococcosis, a
zoonosis affecting humans and domestic animals worldwide-is an excellent model for the …

Schistosoma mansoni is a blood fluke parasite that causes schistosomiasis, a debilitating
disease of global public health importance. These relatively large parasites are able to …

Background The chemotherapy of schistosomiasis currently depends on the use of a single
drug, praziquantel. In order to develop novel chemotherapeutic agents we are investigating …

An identical 36-nucleotide exon was identified at the 5′ termini of different mRNAs from the
cestodeEchinococcus multilocularis. We provide evidence that this exon constitutes a new …