There are ample genetic and laboratory studies that suggest the PI3K–Akt pathway is vital to
the growth and survival of cancer cells. Inhibitors targeting this pathway are entering the …

▪ Abstract The phosphoinositide 3-kinase (PI3K) family of enzymes is recruited upon growth
factor receptor activation and produces 3′ phosphoinositide lipids. The lipid products of …

▪ Abstract The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …

Endocrine therapy is a crucial treatment for estrogen receptor-positive (ER+) breast cancer,
with proven clinical benefits. However, adaptive mechanisms emerge in the tumor, causing …

The Class III PI3K (phosphoinositide 3-kinase), Vps34 (vacuolar protein sorting 34), was first
described as a component of the vacuolar sorting system in Saccharomyces cerevisiae and …

On activation by receptors, the ubiquitously expressed class IA isoforms (p110α and p110β)
of phosphatidylinositol-3-OH kinase (PI (3) K) generate lipid second messengers, which …

Many signaling pathways converge on and regulate phosphoinositide 3-kinase (PI3K)
enzymes whose inositol lipid products are key mediators of intracellular signaling. Different …

Background Despite significant advances in molecular characterization and therapeutic
targeting of advanced prostate cancer, it remains the second most common cause of cancer …

The eight catalytic subunits of the mammalian phosphoinositide-3-OH kinase (PI (3) K)
family form the backbone of an evolutionarily conserved signalling pathway; however, the …

The p110 isoforms of phosphoinositide 3-kinase (PI3K) are acutely regulated by
extracellular stimuli. The class IA PI3K catalytic subunits (p110α, p110β, and p110δ) occur in …