Epithelial-mesenchymal transition (EMT) and its critical roles during cancer progression
have long been recognized and extensively reviewed. Recent studies on the generation of …

Histone posttranslational modifications are key regulators of chromatin-associated
processes including gene expression, DNA replication and DNA repair. Monoubiquitinated …

Control of stem cell-associated genes by Trithorax group (TrxG) and Polycomb group (PcG)
proteins is frequently misregulated in cancer. In leukemia, oncogenic fusion proteins hijack …

α-Ketoglutarate is an important metabolic intermediate that acts as a cofactor for several
chromatin-modifying enzymes, including histone demethylases and the Tet family of …

BMP4 regulates a plethora of developmental processes, including the dorsal–ventral axis
and neural patterning. Here, we report that BMP4 reconfigures the nuclear architecture …

The discovery of histone demethylases has revealed the dynamic nature of the regulation of
histone methylation. KDM2B is an important histone lysine demethylase that removes methyl …

Elucidating the mechanism of reprogramming is confounded by heterogeneity due to the low
efficiency and differential kinetics of obtaining induced pluripotent stem cells (iPSCs) from …

The chromatin structure of the mammalian genome must facilitate both precisely-controlled
DNA replication together with tightly-regulated gene transcription. This necessarily involves …

Polycomb group (PcG) proteins are essential for post-implantation development by
depositing repressive histone modifications at promoters, mainly CpG islands (CGIs), of …

Aberrant levels of histone modifications lead to chromatin malfunctioning and consequently
to various developmental defects and human diseases. Therefore, the proteins bearing the …