The biology of forgetting—a perspective
RL Davis, Y Zhong - Neuron, 2017 - cell.com
Pioneering research studies, beginning with those using Drosophila, have identified several
molecular and cellular mechanisms for active forgetting. The currently known mechanisms …
molecular and cellular mechanisms for active forgetting. The currently known mechanisms …
Control of synapse development and plasticity by Rho GTPase regulatory proteins
Synapses are specialized cell–cell contacts that mediate communication between neurons.
Most excitatory synapses in the brain are housed on dendritic spines, small actin-rich …
Most excitatory synapses in the brain are housed on dendritic spines, small actin-rich …
When is the hippocampus involved in recognition memory?
GRI Barker, EC Warburton - Journal of Neuroscience, 2011 - Soc Neuroscience
The role of the hippocampus in recognition memory is controversial. Recognition memory
judgments may be made using different types of information, including object familiarity, an …
judgments may be made using different types of information, including object familiarity, an …
Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice
Major depressive disorder is associated with abnormalities in the brain and the immune
system. Chronic stress in animals showed that epigenetic and inflammatory mechanisms …
system. Chronic stress in animals showed that epigenetic and inflammatory mechanisms …
Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis
WG Wood, L Li, WE Müller… - Journal of …, 2014 - Wiley Online Library
High serum/plasma cholesterol levels have been suggested as a risk factor for Alzheimer's
disease (AD). Some reports, mostly retrospective epidemiological studies, have observed a …
disease (AD). Some reports, mostly retrospective epidemiological studies, have observed a …
A meta-analysis of brain DNA methylation across sex, age, and Alzheimer's disease points for accelerated epigenetic aging in neurodegeneration
C Pellegrini, C Pirazzini, C Sala, L Sambati… - Frontiers in aging …, 2021 - frontiersin.org
Alzheimer's disease (AD) is characterized by specific alterations of brain DNA methylation
(DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect …
(DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect …
Rho signaling in synaptic plasticity, memory, and brain disorders
Memory impairments are associated with many brain disorders such as autism, Alzheimer's
disease, and depression. Forming memories involves modifications of synaptic transmission …
disease, and depression. Forming memories involves modifications of synaptic transmission …
The role of c-Abl tyrosine Kinase in brain and its pathologies
H Motaln, B Rogelj - Cells, 2023 - mdpi.com
Differentiated status, low regenerative capacity and complex signaling make neuronal
tissues highly susceptible to translating an imbalance in cell homeostasis into cell death …
tissues highly susceptible to translating an imbalance in cell homeostasis into cell death …
Memory suppressor genes: modulating acquisition, consolidation, and forgetting
The brain has a remarkable but underappreciated capacity to limit memory formation and
expression. The term" memory suppressor gene" was coined in 1998 as an attempt to …
expression. The term" memory suppressor gene" was coined in 1998 as an attempt to …
[HTML][HTML] Huntingtin coordinates dendritic spine morphology and function through cofilin-mediated control of the actin cytoskeleton
D Wennagel, BY Braz, M Capizzi, M Barnat, S Humbert - Cell Reports, 2022 - cell.com
Compelling evidence indicates that in Huntington's disease (HD), mutation of huntingtin
(HTT) alters several aspects of early brain development such as synaptogenesis. It is not …
(HTT) alters several aspects of early brain development such as synaptogenesis. It is not …