Oxidatively damaged DNA results from the attack of sugar and base moieties by reactive
oxygen species (ROS), which are formed as byproducts of normal cell metabolism and …

7, 8-Dihydro-8-oxoguanine (oxoG) is the most abundant oxidative DNA lesion with dual
coding properties. It forms both Watson–Crick (anti) oxoG:(anti) C and Hoogsteen (syn) …

The SARS-CoV-2 coronavirus is an enveloped, positive-sense single-stranded RNA virus
that is responsible for the COVID-19 pandemic. The spike is a class I viral fusion …

8-Oxo-7, 8-dihydroguanine (oxoG), an abundant DNA lesion, can mispair with adenine and
induce mutations. To prevent this, cells possess DNA repair glycosylases that excise either …

In cellular organisms composition of DNA is constrained to only four nucleobases A, G, T
and C, except for minor DNA base modifications such as methylation which serves for …

8-Oxoguanine (8-oxoG), a mutagenic DNA lesion generated under oxidative stress, differs
from its precursor guanine by only two substitutions (O8 and H7). Human 8-oxoguanine …

We present a fast implementation of the nudged elastic band (NEB) method into the particle
mesh Ewald molecular dynamics module of the Amber software package for both central …

Human alkyladenine DNA glycosylase (AAG) is a key enzyme that corrects a broad range of
alkylated and deaminated nucleobases to maintain genomic integrity. When encountering …

X-ray data show that DNA glycosylases, which initiate the pathway of base excision repair in
DNA, belong to six structural superfamilies. Here, we provide an overview of the latest …

Formamidopyrimidine DNA glycosylase (FPG) is a crucial DNA repair enzyme that
specifically recognizes and excises the damaged base 7, 8-dihydro-8-oxoguanine (8-oxoG) …