Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation
Human gut commensals are increasingly suggested to impact non-communicable diseases,
such as inflammatory bowel diseases (IBD), yet their targeted suppression remains a …
such as inflammatory bowel diseases (IBD), yet their targeted suppression remains a …
β-Hydroxybutyrate suppresses colorectal cancer
Colorectal cancer (CRC) is among the most frequent forms of cancer, and new strategies for
its prevention and therapy are urgently needed. Here we identify a metabolite signalling …
its prevention and therapy are urgently needed. Here we identify a metabolite signalling …
Chemically induced mouse models of acute and chronic intestinal inflammation
S Wirtz, V Popp, M Kindermann, K Gerlach… - Nature protocols, 2017 - nature.com
Inflammatory bowel diseases (IBDs) result in diarrhea and abdominal pain with further
potential complications such as tissue fibrosis and stenosis. Animal models help in …
potential complications such as tissue fibrosis and stenosis. Animal models help in …
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
Rheumatoid arthritis (RA) is a prevalent systemic autoimmune disease, caused by a
combination of genetic and environmental factors. Animal models suggest a role for …
combination of genetic and environmental factors. Animal models suggest a role for …
[HTML][HTML] NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
Inflammasomes are multiprotein complexes that function as sensors of endogenous or
exogenous damage-associated molecular patterns. Here, we show that deficiency of NLRP6 …
exogenous damage-associated molecular patterns. Here, we show that deficiency of NLRP6 …
Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease
Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis
(UC), are complex chronic inflammatory conditions of the gastrointestinal tract that are driven …
(UC), are complex chronic inflammatory conditions of the gastrointestinal tract that are driven …
Chemically induced mouse models of intestinal inflammation
S Wirtz, C Neufert, B Weigmann, MF Neurath - Nature protocols, 2007 - nature.com
Animal models of intestinal inflammation are indispensable for our understanding of the
pathogenesis of Crohn disease and ulcerative colitis, the two major forms of inflammatory …
pathogenesis of Crohn disease and ulcerative colitis, the two major forms of inflammatory …
Epithelial IL-18 equilibrium controls barrier function in colitis
The intestinal mucosal barrier controlling the resident microbiome is dependent on a
protective mucus layer generated by goblet cells, impairment of which is a hallmark of the …
protective mucus layer generated by goblet cells, impairment of which is a hallmark of the …
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
Chronic mucosal inflammation and tissue damage predisposes patients to the development
of colorectal cancer. This association could be explained by the hypothesis that the same …
of colorectal cancer. This association could be explained by the hypothesis that the same …
Ly6Chi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells
Ly6C hi monocytes seed the healthy intestinal lamina propria to give rise to resident CX 3
CR1+ macrophages that contribute to the maintenance of gut homeostasis. Here we report …
CR1+ macrophages that contribute to the maintenance of gut homeostasis. Here we report …