Bone marrow mesenchymal stem cells: historical overview and concepts

P Charbord - Human gene therapy, 2010 - liebertpub.com
This review describes the historical emergence of the concept of bone marrow
mesenchymal stem cells (MSCs), summarizing data on Wolf and Trentin's hematopoietic …

Natural history of mesenchymal stem cells, from vessel walls to culture vessels

IR Murray, CC West, WR Hardy, AW James… - Cellular and Molecular …, 2014 - Springer
Mesenchymal stem/stromal cells (MSCs) can regenerate tissues by direct differentiation or
indirectly by stimulating angiogenesis, limiting inflammation, and recruiting tissue-specific …

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

MJ Workman, MM Mahe, S Trisno, HM Poling… - Nature medicine, 2017 - nature.com
The enteric nervous system (ENS) of the gastrointestinal tract controls many diverse
functions, including motility and epithelial permeability. Perturbations in ENS development …

Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma

J Wouters, Z Kalender-Atak, L Minnoye, KI Spanier… - Nature Cell …, 2020 - nature.com
Melanoma cells can switch between a melanocytic and a mesenchymal-like state. Scattered
evidence indicates that additional intermediate state (s) may exist. Here, to search for such …

Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs

G Lee, EP Papapetrou, H Kim, SM Chambers… - nature, 2009 - nature.com
The isolation of human induced pluripotent stem cells (iPSCs),, offers a new strategy for
modelling human disease. Recent studies have reported the derivation and differentiation of …

Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors

SM Chambers, Y Qi, Y Mica, G Lee, XJ Zhang… - Nature …, 2012 - nature.com
Considerable progress has been made in identifying signaling pathways that direct the
differentiation of human pluripotent stem cells (hPSCs) into specialized cell types, including …

Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor

KL Ring, LM Tong, ME Balestra, R Javier… - Cell stem cell, 2012 - cell.com
The generation of induced pluripotent stem cells (iPSCs) and induced neuronal cells (iNCs)
from somatic cells provides new avenues for basic research and potential transplantation …

Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma

O Marin-Bejar, A Rogiers, M Dewaele, J Femel… - Cancer Cell, 2021 - cell.com
Therapy resistance arises from heterogeneous drug-tolerant persister cells or minimal
residual disease (MRD) through genetic and nongenetic mechanisms. A key question is …