Pharmaco-immunomodulatory therapy in COVID-19

JG Rizk, K Kalantar-Zadeh, MR Mehra, CJ Lavie… - Drugs, 2020 - Springer
The severe acute respiratory syndrome coronavirus 2 associated coronavirus disease 2019
(COVID-19) illness is a syndrome of viral replication in concert with a host inflammatory …

Statins: could an old friend help in the fight against COVID‐19?

RR Rodrigues‐Diez, A Tejera‐Muñoz… - British journal of …, 2020 - Wiley Online Library
The COVID‐19 pandemic caused by the severe acute respiratory syndrome coronavirus 2
(SARS‐CoV‐2) has overwhelmed healthcare systems requiring the rapid development of …

Association of COVID-19 with major arterial and venous thrombotic diseases: a population-wide cohort study of 48 million adults in England and Wales

R Knight, V Walker, S Ip, JA Cooper, T Bolton… - Circulation, 2022 - ahajournals.org
Background: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
induces a prothrombotic state, but long-term effects of COVID-19 on incidence of vascular …

In-hospital use of statins is associated with a reduced risk of mortality among individuals with COVID-19

XJ Zhang, JJ Qin, XU Cheng, L Shen, YC Zhao, Y Yuan… - Cell metabolism, 2020 - cell.com
Statins are lipid-lowering therapeutics with favorable anti-inflammatory profiles and have
been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk …

Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19

A Gupta, MV Madhavan, TJ Poterucha… - Nature …, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) can result in a hyperinflammatory state,
leading to acute respiratory distress syndrome (ARDS), myocardial injury, and thrombotic …

The prognostic value of comorbidity for the severity of COVID-19: A systematic review and meta-analysis study

M Fathi, K Vakili, F Sayehmiri, A Mohamadkhani… - PloS one, 2021 - journals.plos.org
Background and objectives With the increase in the number of COVID-19 infections, the
global health apparatus is facing insufficient resources. The main objective of the current …

Improved COVID‐19 outcomes following statin therapy: an updated systematic review and meta‐analysis

A Vahedian-Azimi, SM Mohammadi… - BioMed research …, 2021 - Wiley Online Library
Background. Although vaccine rollout for COVID‐19 has been effective in some countries,
there is still an urgent need to reduce disease transmission and severity. We recently carried …

Statin therapy did not improve the in-hospital outcome of coronavirus disease 2019 (COVID-19) infection

TI Hariyanto, A Kurniawan - … & Metabolic Syndrome: Clinical Research & …, 2020 - Elsevier
Background and aims The coronavirus disease 2019 (COVID-19) number of death cases is
still increasing. One of the comorbidities associated with severe outcome and mortality of …

Statin use is associated with lower disease severity in COVID-19 infection

WYT Tan, BE Young, DC Lye, DEK Chew, R Dalan - Scientific reports, 2020 - nature.com
We aim to study the association of hyperlipidemia and statin use with COVID-19 severity. We
analysed a retrospective cohort of 717 patients admitted to a tertiary centre in Singapore for …

[HTML][HTML] Endothelial dysfunction in COVID-19: Current findings and therapeutic implications

MP Nägele, B Haubner, FC Tanner, F Ruschitzka… - atherosclerosis, 2020 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) increases the risk of several non-pulmonary
complications such as acute myocardial injury, renal failure or thromboembolic events. A …