Despite advances in genetic and proteomic techniques, a complete portrait of the proteome
and its complement of dynamic interactions and modifications remains a lofty, and as of yet …

Genome sequencing projects have provided researchers with a complete inventory of the
predicted proteins produced by eukaryotic and prokaryotic organisms. Assignment of …

Branched fatty acid (FA) esters of hydroxy FAs (HFAs; FAHFAs) are recently discovered
lipids that are conserved from yeast to mammals,. A subfamily, palmitic acid esters of …

Tumor cells display progressive changes in metabolism that correlate with malignancy,
including development of a lipogenic phenotype. How stored fats are liberated and …

Eukaryotic and prokaryotic organisms possess huge numbers of uncharacterized enzymes.
Selective inhibitors offer powerful probes for assigning functions to enzymes in native …

Endogenous ligands for cannabinoid receptors (" endocannabinoids") include the lipid
transmitters anandamide and 2-arachidonoylglycerol (2-AG). Endocannabinoids modulate a …

Arachidonoylglycerol (2-AG) and anandamide are endocannabinoids that activate the
cannabinoid receptors CB1 and CB2. Endocannabinoid signaling is terminated by …

Serine hydrolases (SHs) consist of> 200 enzymes in humans characterized by the presence
of an active site serine that is used for the hydrolysis of substrates. The membership of this …

In recent years, a number of bioorthogonal reactions have been developed, exemplified by
click chemistry, that enable the efficient formation of a specific product, even within a highly …

Abstract The endocannabinoid 2-arachidonoylglycerol (2-AG) regulates neurotransmission
and neuroinflammation by activating CB1 cannabinoid receptors on neurons and CB2 …