Lipophilicity and its relationship with passive drug permeation
X Liu, B Testa, A Fahr - Pharmaceutical research, 2011 - Springer
In this review, we first summarize the structure and properties of biological membranes and
the routes of passive drug transfer through physiological barriers. Lipophilicity is then …
the routes of passive drug transfer through physiological barriers. Lipophilicity is then …
Physicochemical profiling (solubility, permeability and charge state)
A Avdeef - Current topics in medicinal chemistry, 2001 - ingentaconnect.com
About 30per4cent of drug candidate molecules are rejected due to pharmacokinetic-related
failures. When poor pharmaceutical properties are discovered in development, the costs of …
failures. When poor pharmaceutical properties are discovered in development, the costs of …
Choose your label wisely: water-soluble fluorophores often interact with lipid bilayers
Water-soluble organic fluorophores are widely used as labels in biological systems.
However, in many cases these fluorophores can interact strongly with lipid bilayers …
However, in many cases these fluorophores can interact strongly with lipid bilayers …
[LIBRO][B] Absorption and drug development: solubility, permeability, and charge state
A Avdeef - 2012 - books.google.com
Explains how to perform and analyze the results of the latest physicochemical methods With
this book as their guide, readers have access to all the current information needed to …
this book as their guide, readers have access to all the current information needed to …
pH-Metric logP 10. Determination of liposomal membrane-water partition coefficients of lonizable drugs
A Avdeef, KJ Box, JEA Comer, C Hibbert… - Pharmaceutical …, 1998 - Springer
Purpose. To investigate a novel approach for the determination of liposomal membrane-
water partition coefficients and lipophilicity profiles of ionizable drugs. Methods. The …
water partition coefficients and lipophilicity profiles of ionizable drugs. Methods. The …
Capacities of membrane lipids to accumulate neutral organic chemicals
Lipids have been considered as the predominant components for bioaccumulation of
organic chemicals. However, differences in accumulation properties between different types …
organic chemicals. However, differences in accumulation properties between different types …
Removal of beta-blockers from aqueous media by adsorption onto graphene oxide
GZ Kyzas, A Koltsakidou, SG Nanaki… - Science of the Total …, 2015 - Elsevier
The aim of the present study is the evaluation of graphene oxide (GhO) as adsorbent
material for the removal of beta-blockers (pharmaceutical compounds) in aqueous solutions …
material for the removal of beta-blockers (pharmaceutical compounds) in aqueous solutions …
Detection of PPCPs in marine organisms from contaminated coastal waters of the Saudi Red Sea
The occurrence of PPCPs in macroalgae, barnacle and fish samples from contaminated
coastal waters of the Saudi Red Sea is reported. Solvent extraction followed by solid phase …
coastal waters of the Saudi Red Sea is reported. Solvent extraction followed by solid phase …
Liquid chromatography on the different methods for the determination of lipophilicity: An essential analytical tool in medicinal chemistry
Lipophilicity is one of many parameters involved in the biological activity of drugs, as it
affects their pharmacokinetic and pharmacodynamic behavior. Generally, lipophilicity is …
affects their pharmacokinetic and pharmacodynamic behavior. Generally, lipophilicity is …
[LIBRO][B] Liquid interfaces in chemical, biological and pharmaceutical applications
AG Volkov - 2001 - books.google.com
Provides a comprehensive treatment of surface chemistry and its applications to chemical
engineering, biology, and medicine. Focuses on the chmical and physical structure of oil …
engineering, biology, and medicine. Focuses on the chmical and physical structure of oil …