abstract Bronchial asthma is characterized by persistent cough, increased sputum, and
repeated wheezing. The pathophysiology underlying these symptoms is the hyper …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein
substitution D614G became dominant during the coronavirus disease 2019 (COVID-19) …

The lung is an organ that is directly exposed to the external environment. Given the large
surface area and extensive ventilation of the lung, it is prone to exposure to airborne …

Rhinoviruses and allergens, such as house dust mite are major agents responsible for
asthma exacerbations. The influence of pre-existing airway inflammation on the infection …

Background Tight junctions (TJs) form a barrier on the apical side of neighboring epithelial
cells in the bronchial mucosa. Changes in their integrity might play a role in asthma …

Respiratory viral infections, particularly those caused by rhinovirus, exacerbate chronic
respiratory inflammatory diseases, such as asthma and chronic obstructive pulmonary …

Models of the outer epithelia of the human body-namely the skin, the intestine and the lung-
have found valid applications in both research and industrial settings as attractive …

Current limitations to primary cell expansion led us to test whether airway epithelial cells
derived from healthy children and those with asthma and cystic fibrosis (CF), co-cultured …

A spike protein mutation D614G became dominant in SARS-CoV-2 during the COVID-19
pandemic. However, the mutational impact on viral spread and vaccine efficacy remains to …

The human bronchial epithelium is composed of multiple distinct cell types that cooperate to
defend against environmental insults. While studies have shown that smoking alters …