Current trends in natural products for the treatment and management of dementia: Computational to clinical studies

RK Singla, S Joon, B Sinha, MA Kamal… - Neuroscience & …, 2023 - Elsevier
The number of preclinical and clinical studies evaluating natural products-based
management of dementia has gradually increased, with an exponential rise in 2020 and …

[HTML][HTML] Bioactivity and Mycochemical Profile of Extracts from Mycelial Cultures of Ganoderma spp.

K Sułkowska-Ziaja, G Zengin, A Gunia-Krzyżak… - Molecules, 2022 - mdpi.com
Fungal mycelium cultures are an alternative to natural sources in order to obtain valuable
research materials. They also enable constant control and adaptation of the process …

Ethosomes: Novel Vesicular Carriers for Effective Transdermal Delivery of Natural Therapeutics

S Bhatia, V Singh, M Singh, D Singh… - Letters in Drug …, 2024 - ingentaconnect.com
The topical delivery, being the most reliable route for drug administration, offers multiple
advantages. The conventional topical dosage forms deliver a relatively higher amount of …

[HTML][HTML] Isolation of Pleurotus florida derived acetylcholinesterase inhibitor for the treatment of cognitive dysfunction in mice

K Randhawa, V Singh, S Kaur, R Kaur, S Kumar… - Food Science and …, 2021 - Elsevier
Our earlier work showed that hydromethanol extract (HME) of Pleurotus florida had
antioxidant and anti-cholinesterase potential. This study aimed at isolating the constituent …

[HTML][HTML] 3-hydroxy-3′, 4′, 5′-trimethoxyflavone protects rats against lead-induced neurotoxicity via chelation and modulating oxidative stress, inflammatory and …

V Singh, R Shri, P Sood, M Singh, TG Singh… - Journal of Functional …, 2024 - Elsevier
Lead (Pb) is known to cause neurological changes, but antioxidants, chelators, and anti-
inflammatory agents mitigates Pb toxicity. Previously, we reported antioxidant and anti …

Trimethoxyflavones from Ocimum basilicum L. leaves improve long term memory in mice by modulating multiple pathways

V Singh, K Kaur, S Kaur, R Shri, TG Singh… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Traditionally, Ocimum basilicum L. leaves (OB)
are recommended for various brain disorders. Aim of the study Scientific evidence highlights …

Exploring the molecular mechanisms underlying neuroprotective effect of ellagic acid in okadaic acid-induced Alzheimer's phenotype

T Baluchnejadmojarad, M Roghani - Metabolic Brain Disease, 2024 - Springer
Pomegranate polyphenol ellagic acid has medicinal potential in neurodegenerative
disorders. The advantageous effect of this polyphenol in improving cognition in okadaic acid …

Effect-directed profiling of 17 different fortified plant extracts by high-performance thin-layer chromatography combined with six planar assays and high-resolution …

GE Morlock, J Heil, V Bardot, L Lenoir, C Cotte… - Molecules, 2021 - mdpi.com
An effect-directed profiling method was developed to investigate 17 different fortified plant
extracts for potential benefits. Six planar effect-directed assays were piezoelectrically …

Nanodisc-associated acetylcholinesterase as a novel model system of physiological relevant membrane-bound cholinesterases. Inhibition by phenolic compounds

PB Salazar, FG Dupuy, MC Fiori, SM Stanfield… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Acetylcholinesterase (AChE) plays a pivotal role in the cholinergic system, and its inhibition
is sought after in a wide range of applications, from insect control to Alzheimer's disease …

Morus Alba Fruit Extract and its Fractions Ameliorate Streptozotocin Induced Cognitive Deficit in Mice via Modulating Oxidative and Cholinergic Systems

P Sood, V Singh, R Shri - Neurochemical Research, 2024 - Springer
Increased oxidative stress and acetylcholinesterase (AChE) activity are key pathological
characters contributing to the memory disorders. Thus, drugs targeting both oxidative stress …