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Current trends in natural products for the treatment and management of dementia: Computational to clinical studies
The number of preclinical and clinical studies evaluating natural products-based
management of dementia has gradually increased, with an exponential rise in 2020 and …
management of dementia has gradually increased, with an exponential rise in 2020 and …
[HTML][HTML] Bioactivity and Mycochemical Profile of Extracts from Mycelial Cultures of Ganoderma spp.
K Sułkowska-Ziaja, G Zengin, A Gunia-Krzyżak… - Molecules, 2022 - mdpi.com
Fungal mycelium cultures are an alternative to natural sources in order to obtain valuable
research materials. They also enable constant control and adaptation of the process …
research materials. They also enable constant control and adaptation of the process …
Ethosomes: Novel Vesicular Carriers for Effective Transdermal Delivery of Natural Therapeutics
The topical delivery, being the most reliable route for drug administration, offers multiple
advantages. The conventional topical dosage forms deliver a relatively higher amount of …
advantages. The conventional topical dosage forms deliver a relatively higher amount of …
[HTML][HTML] Isolation of Pleurotus florida derived acetylcholinesterase inhibitor for the treatment of cognitive dysfunction in mice
Our earlier work showed that hydromethanol extract (HME) of Pleurotus florida had
antioxidant and anti-cholinesterase potential. This study aimed at isolating the constituent …
antioxidant and anti-cholinesterase potential. This study aimed at isolating the constituent …
[HTML][HTML] 3-hydroxy-3′, 4′, 5′-trimethoxyflavone protects rats against lead-induced neurotoxicity via chelation and modulating oxidative stress, inflammatory and …
Lead (Pb) is known to cause neurological changes, but antioxidants, chelators, and anti-
inflammatory agents mitigates Pb toxicity. Previously, we reported antioxidant and anti …
inflammatory agents mitigates Pb toxicity. Previously, we reported antioxidant and anti …
Trimethoxyflavones from Ocimum basilicum L. leaves improve long term memory in mice by modulating multiple pathways
Abstract Ethnopharmacological relevance Traditionally, Ocimum basilicum L. leaves (OB)
are recommended for various brain disorders. Aim of the study Scientific evidence highlights …
are recommended for various brain disorders. Aim of the study Scientific evidence highlights …
Exploring the molecular mechanisms underlying neuroprotective effect of ellagic acid in okadaic acid-induced Alzheimer's phenotype
T Baluchnejadmojarad, M Roghani - Metabolic Brain Disease, 2024 - Springer
Pomegranate polyphenol ellagic acid has medicinal potential in neurodegenerative
disorders. The advantageous effect of this polyphenol in improving cognition in okadaic acid …
disorders. The advantageous effect of this polyphenol in improving cognition in okadaic acid …
Effect-directed profiling of 17 different fortified plant extracts by high-performance thin-layer chromatography combined with six planar assays and high-resolution …
GE Morlock, J Heil, V Bardot, L Lenoir, C Cotte… - Molecules, 2021 - mdpi.com
An effect-directed profiling method was developed to investigate 17 different fortified plant
extracts for potential benefits. Six planar effect-directed assays were piezoelectrically …
extracts for potential benefits. Six planar effect-directed assays were piezoelectrically …
Nanodisc-associated acetylcholinesterase as a novel model system of physiological relevant membrane-bound cholinesterases. Inhibition by phenolic compounds
PB Salazar, FG Dupuy, MC Fiori, SM Stanfield… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Acetylcholinesterase (AChE) plays a pivotal role in the cholinergic system, and its inhibition
is sought after in a wide range of applications, from insect control to Alzheimer's disease …
is sought after in a wide range of applications, from insect control to Alzheimer's disease …
Morus Alba Fruit Extract and its Fractions Ameliorate Streptozotocin Induced Cognitive Deficit in Mice via Modulating Oxidative and Cholinergic Systems
Increased oxidative stress and acetylcholinesterase (AChE) activity are key pathological
characters contributing to the memory disorders. Thus, drugs targeting both oxidative stress …
characters contributing to the memory disorders. Thus, drugs targeting both oxidative stress …