Coronary microvascular endothelial dysfunction is both a culprit and a victim of diabetes,
and can accelerate diabetes-related microvascular and macrovascular complications by …

Mitochondria have emerged as a central factor in the pathogenesis and progression of heart
failure, and other cardiovascular diseases, as well, but no therapies are available to treat …

Rationale: Hypertension represents a major risk factor for stroke, myocardial infarction, and
heart failure and affects 30% of the adult population. Mitochondrial dysfunction contributes to …

Mitochondria provide energy to the cell during aerobic respiration by supplying~ 95% of the
adenosine triphosphate (ATP) molecules via oxidative phosphorylation. These organelles …

The ageing process is accompanied by the gradual development of chronic systemic
inflammation (inflamm-ageing). Growth differentiation factor 15 (GDF15) is associated with …

Shortened telomeres have been linked to numerous chronic diseases, most importantly
coronary artery disease, but the underlying mechanisms remain ill defined. Loss-of-function …

Vascular endothelial cells line the inner surface of the entire cardiovascular system as a
single layer and are involved in an impressive array of functions, ranging from the regulation …

Myalgic encephalomyelitis/chronic fatigue syndrome is a serious illness of unknown
etiology, characterized by debilitating exhaustion, memory impairment, pain and sleep …

Many anticancer therapies (CTx) have cardiotoxic side effects that limit their therapeutic
potential and cause long-term cardiovascular complications in cancer survivors. This has …

Objectives: Short-chain fatty acids (SCFAs), the main metabolites released from the gut
microbiota, are altered during hypertension and obesity. SCFAs play a beneficial role in the …