Synthesis and glycosidation of anomeric halides: evolution from early studies to modern methods of the 21st century

Y Singh, SA Geringer, AV Demchenko - Chemical reviews, 2022 - ACS Publications
Advances in synthetic carbohydrate chemistry have dramatically improved access to
common glycans. However, many novel methods still fail to adequately address challenges …

Automated chemical oligosaccharide synthesis: novel approach to traditional challenges

M Panza, SG Pistorio, KJ Stine… - Chemical reviews, 2018 - ACS Publications
Advances in carbohydrate chemistry have certainly made common oligosaccharides much
more accessible. However, many current methods still rely heavily upon specialized …

Synthetic microbial consortia: from systematic analysis to construction and applications

H Song, MZ Ding, XQ Jia, Q Ma, YJ Yuan - Chemical Society Reviews, 2014 - pubs.rsc.org
Synthetic biology is an emerging research field that focuses on using rational engineering
strategies to program biological systems, conferring on them new functions and behaviours …

Enzymatic methods for glyco (diversification/randomization) of drugs and small molecules

RW Gantt, P Peltier-Pain, JS Thorson - Natural product reports, 2011 - pubs.rsc.org
Covering: up to the end of May 2011 Glyco (randomization/diversification) is a term that
encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to …

Application of carbohydrates in approved small molecule drugs: A review

H Jiang, X Qin, Q Wang, Q Xu, J Wang, Y Wu… - European Journal of …, 2021 - Elsevier
Carbohydrates are an important energy source and play numerous key roles in all living
organisms. Carbohydrates chemistry involved in diagnosis and treatment of diseases has …

Synthesis of N‐Glycosides by Silver‐Assisted Gold Catalysis

S Chakraborty, B Mishra, P Kumar Das… - Angewandte Chemie …, 2023 - Wiley Online Library
The synthesis of N‐glycosides from stable glycosyl donors in a catalytic fashion is still
challenging, though they exist ubiquitously in DNA, RNA, glycoproteins, and other biological …

Mechanism of chemical glycosylation: focus on the mode of activation and departure of anomeric leaving groups

SC Ranade, AV Demchenko - Journal of Carbohydrate Chemistry, 2013 - Taylor & Francis
Many glycosyl donors used in chemical glycosylation are too stable to undergo spontaneous
glycosylation. Hence, the first key step of practically every glycosylation reaction is the …

Therapeutic potential of pectin and its derivatives in chronic diseases

A Dambuza, P Rungqu, AO Oyedeji, G Miya, AO Oriola… - Molecules, 2024 - mdpi.com
Non-communicable diseases (NCDs) are described as a collection of chronic diseases that
do not typically develop from an acute infection, have long-term health effects, and …

The structural biology of enzymes involved in natural product glycosylation

S Singh, GN Phillips Jr, JS Thorson - Natural Product Reports, 2012 - pubs.rsc.org
Covering: up to 2012 The glycosylation of microbial natural products often dramatically
influences the biological and/or pharmacological activities of the parental metabolite. Over …

Post-screening characterisation and in vivo evaluation of an anti-inflammatory polysaccharide fraction from Eucommia ulmoides

Q Li, Y Feng, W He, L Wang, R Wang, L Dong… - Carbohydrate …, 2017 - Elsevier
We report here the discovery of a polysaccharide, namely EUP1, with anti-inflammatory
activity from the herb of Eucommia ulmoides Oliv. We separated three polysaccharide …