Ethnopharmacological relevance Catharanthus roseus (L.) G. Don is a well known
medicinal plant belonging to family Apocynaceae that have been traditionally used as …

Catharanthus roseus is a medicinal plant belonging to the family Apocynaceae which
produces terpenoid indole alkaloids (TIAs) of high medicinal importance. Indeed, a number …

Vinblastine, a potent anticancer drug, is produced by Catharanthus roseus (Madagascar
periwinkle) in small quantities, and heterologous reconstitution of vinblastine biosynthesis …

Chemistry and biology of monoterpene indole alkaloid biosynthesis - Natural Product Reports
(RSC Publishing) DOI:10.1039/B512615K Royal Society of Chemistry View PDF …

Monoterpenoid indole alkaloids (MIAs) possess a diversity of alkaloid skeletons whose
biosynthesis is poorly understood. A bioinformatic search of candidate genes, combined …

Rational engineering of complicated metabolic networks involved in the production of
biologically active plant compounds has been greatly impeded by our poor understanding of …

Catharanthus roseus is still the only source for the powerful antitumour drugs vinblastine
and vincristine. Some other pharmaceutical compounds from this plant, ajmalicine and …

Due to their complex structure with several chiral centres important anticancer agents are
still extracted from plants and not synthesized chemically on a commercial scale …

Covering: up to February 2022 Naturally occurring dimeric molecules attract considerable
attention from both chemists and biologists. The methylene-bridged dimers with one-carbon …

Catharanthus roseus plants produce many pharmaceutically important indole alkaloids, of
which the bisindole alkaloids vinblastine and vincristine are antineoplastic medicines and …