Pleiotropy (whereby one genetic polymorphism affects multiple traits) and epistasis
(whereby non-linear interactions between genetic polymorphisms affect the same trait) are …

The wide variety of animal behaviours that can be observed today arose through the
evolution of their underlying neural circuits. Advances in understanding the mechanisms …

FlyBase provides a centralized resource for the genetic and genomic data of Drosophila
melanogaster. As FlyBase enters our fourth decade of service to the research community …

Chromatin topology is intricately linked to gene expression, yet its functional requirement
remains unclear. Here, we comprehensively assessed the interplay between genome …

Direct observation of evolution in response to natural environmental change can resolve
fundamental questions about adaptation, including its pace, temporal dynamics, and …

As populations diverge, genetic differences accumulate across the genome. Spurred by
rapid developments in sequencing technology, genome-wide population surveys of natural …

Genomes assembled de novo from short reads are highly fragmented relative to the finished
chromosomes of Homo sapiens and key model organisms generated by the Human …

Transposable elements (TEs) are mobile DNA sequences that colonize genomes and
threaten genome integrity. As a result, several mechanisms appear to have emerged during …

The ability to efficiently and accurately determine genotypes is a keystone technology in
modern genetics, crucial to studies ranging from clinical diagnostics, to genotype-phenotype …

Long-read sequencing is driving rapid progress in genome assembly across all major
groups of life, including species of the family Drosophilidae, a longtime model system for …