[HTML][HTML] A systematic review and meta-analysis of somatic and germline DNA sequence biomarkers of esophageal cancer survival, therapy response and stage
JM Findlay, MR Middleton, I Tomlinson - Annals of Oncology, 2015 - Elsevier
Recent advances in next generation sequencing reinforce the potential for DNA sequence
markers to guide esophageal cancer management. We report the first systematic review and …
markers to guide esophageal cancer management. We report the first systematic review and …
Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer
S Marsh, JA McKay, J Cassidy… - … journal of oncology, 2001 - spandidos-publications.com
Thymidylate synthase (TS) is an important target for chemotherapy drugs such as 5-
fluorouracil and raltitrexed. Over-expression of TS has been linked to chemotherapy …
fluorouracil and raltitrexed. Over-expression of TS has been linked to chemotherapy …
Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review
Genetic polymorphisms in the one-carbon folate pathway have been widely studied in
association with a number of conditions. Most of the research has focused on the 677C> T …
association with a number of conditions. Most of the research has focused on the 677C> T …
Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest
Antifolates have a crucial role in the treatment of various cancers by inhibiting key enzymes
in purine and thymidylate biosynthesis. However, the frequent emergence of inherent and …
in purine and thymidylate biosynthesis. However, the frequent emergence of inherent and …
Novel opportunities for thymidylate metabolism as a therapeutic target
For over 40 years, the fluoropyrimidine 5-fluorouracil (5-FU) has remained the central agent
in therapeutic regimens employed in the treatment of colorectal cancer and is frequently …
in therapeutic regimens employed in the treatment of colorectal cancer and is frequently …
Length polymorphism of thymidylate synthase regulatory region in Chinese populations and evolution of the novel alleles
HR Luo, XM Lü, YG Yao, N Horie, K Takeishi… - Biochemical …, 2002 - Springer
The tandemly repeated 28-bp sequence in the 5′-terminal regulatory region of human
thymidylate synthase (TSER), which has been reported to be polymorphic in different …
thymidylate synthase (TSER), which has been reported to be polymorphic in different …
Pharmacokinetic and metabolism determinants of fluoropyrimidines and oxaliplatin activity in treatment of colorectal patients
Fluoropyrimidines and oxaliplatin continued to be the mainstay of therapeutic regimens in
the treatment of colorectal cancer (CRC). For this reason, pharmacokinetic and metabolism …
the treatment of colorectal cancer (CRC). For this reason, pharmacokinetic and metabolism …
[HTML][HTML] Predictive and prognostic markers in colorectal cancer
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in both men and
women in the United States, with an estimated 153,760 new cases predicted for 2007. Since …
women in the United States, with an estimated 153,760 new cases predicted for 2007. Since …
Impact of pharmacogenomics on clinical practice in oncology
S Marsh - Molecular Diagnosis & Therapy, 2007 - Springer
Multiple drug strategies for many cancer types are now readily available and there is a clear
need for tools to inform decision making on therapy selection. Although there is still a long …
need for tools to inform decision making on therapy selection. Although there is still a long …
Beyond thymidylate synthase and dihydrofolate reductase: impact of non-coding microRNAs in anticancer chemoresistance
J Ju - Current enzyme inhibition, 2012 - ingentaconnect.com
Chemoresistance is one of the major reasons for the failure of anticancer chemotherapy in
treating advanced stage cancer. The mechanism of chemoresistance to fluoropyrimidines …
treating advanced stage cancer. The mechanism of chemoresistance to fluoropyrimidines …