High-resolution native mass spectrometry
Native mass spectrometry (MS) involves the analysis and characterization of
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …
Spatially resolved mass spectrometry at the single cell: recent innovations in proteomics and metabolomics
Biological systems are composed of heterogeneous populations of cells that
intercommunicate to form a functional living tissue. Biological function varies greatly across …
intercommunicate to form a functional living tissue. Biological function varies greatly across …
Advances in mass spectrometry imaging for spatial cancer metabolomics
Mass spectrometry (MS) has become a central technique in cancer research. The ability to
analyze various types of biomolecules in complex biological matrices makes it well suited for …
analyze various types of biomolecules in complex biological matrices makes it well suited for …
[HTML][HTML] Identification and characterization of post-translational modifications: Clinical implications
J Hermann, L Schurgers, V Jankowski - Molecular aspects of medicine, 2022 - Elsevier
Post-translational modifications (PTMs) generate marginally modified isoforms of native
peptides, proteins and lipoproteins thereby regulating protein functions, molecular …
peptides, proteins and lipoproteins thereby regulating protein functions, molecular …
[HTML][HTML] Clinical importance of high-mannose, fucosylated, and complex N-glycans in breast cancer metastasis
BACKGROUND. Although aberrant glycosylation is recognized as a hallmark of cancer,
glycosylation in clinical breast cancer (BC) metastasis has not yet been studied. While …
glycosylation in clinical breast cancer (BC) metastasis has not yet been studied. While …
Metabolomics and complementary techniques to investigate the plant phytochemical cosmos
Covering: up to 2021 Plants and their associated microbial communities are known to
produce millions of metabolites, a majority of which are still not characterized and are …
produce millions of metabolites, a majority of which are still not characterized and are …
Imaging and Structural Characterization of Phosphatidylcholine Isomers from Rat Brain Tissue Using Sequential Collision-Induced Dissociation/Electron-Induced …
The chemical complexity of biological tissues creates challenges in the analysis of lipids via
imaging mass spectrometry. The presence of isobaric and isomeric compounds introduces …
imaging mass spectrometry. The presence of isobaric and isomeric compounds introduces …
MALDI-2 on a trapped ion mobility quadrupole time-of-flight instrument for rapid mass spectrometry imaging and ion mobility separation of complex lipid profiles
J Soltwisch, B Heijs, A Koch, S Vens-Cappell… - Analytical …, 2020 - ACS Publications
Matrix-assisted laser desorption/ionization combined with laser-induced postionization
(MALDI-2) is a recently introduced method for enhanced mass spectrometry imaging of …
(MALDI-2) is a recently introduced method for enhanced mass spectrometry imaging of …
MALDI-MSI towards multimodal imaging: challenges and perspectives
Multimodal imaging is a powerful strategy for combining information from multiple images. It
involves several fields in the acquisition, processing and interpretation of images. As …
involves several fields in the acquisition, processing and interpretation of images. As …
Relative quantification of lipid isomers in imaging mass spectrometry using gas-phase charge inversion ion/ion reactions and infrared multiphoton dissociation
Accurate structural identification of lipids in imaging mass spectrometry is critical to properly
contextualizing spatial distributions with tissue biochemistry. Gas-phase charge inversion …
contextualizing spatial distributions with tissue biochemistry. Gas-phase charge inversion …