Revisiting sORFs: overcoming challenges to identify and characterize functional microproteins
Short ORFs (sORFs), that is, occurrences of a start and stop codon within 100 codons or
less, can be found in organisms of all domains of life, outnumbering annotated protein …
less, can be found in organisms of all domains of life, outnumbering annotated protein …
Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames
All species continuously evolve short open reading frames (sORFs) that can be templated
for protein synthesis and may provide raw materials for evolutionary adaptation. We …
for protein synthesis and may provide raw materials for evolutionary adaptation. We …
Cancer-related micropeptides encoded by ncRNAs: Promising drug targets and prognostic biomarkers
S Setrerrahmane, M Li, A Zoghbi, X Lv, S Zhang… - Cancer letters, 2022 - Elsevier
An exciting emerging topic in the noncoding RNA (ncRNA) field is the discovery of short
peptides called micropeptides (≤ 100 amino acids), whose novel therapeutic opportunities …
peptides called micropeptides (≤ 100 amino acids), whose novel therapeutic opportunities …
What can ribo-seq, immunopeptidomics, and proteomics tell us about the noncanonical proteome?
Abstract Ribosome profiling (Ribo-Seq) has proven transformative for our understanding of
the human genome and proteome by illuminating thousands of noncanonical sites of …
the human genome and proteome by illuminating thousands of noncanonical sites of …
Bottom‐up and top‐down proteomic approaches for the identification, characterization, and quantification of the low molecular weight proteome with focus on short …
The recent discovery of alternative open reading frames creates a need for suitable
analytical approaches to verify their translation and to characterize the corresponding gene …
analytical approaches to verify their translation and to characterize the corresponding gene …
[HTML][HTML] Novel insights into noncanonical open reading frames in cancer
Y Liu, S Zeng, M Wu - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
With technological advances, previously neglected noncanonical open reading frames
(nORFs) are drawing ever-increasing attention. However, the translation potential of …
(nORFs) are drawing ever-increasing attention. However, the translation potential of …
Proteoforms expand the world of microproteins and short open reading frame-encoded peptides
Microproteins and short open reading frame-encoded peptides (SEPs) can, like all proteins,
carry numerous posttranslational modifications. Together with posttranscriptional processes …
carry numerous posttranslational modifications. Together with posttranscriptional processes …
Shining a light on the dark proteome: Non‐canonical open reading frames and their encoded miniproteins as a new frontier in cancer biology
In the decades following the discovery that genes encode proteins, scientists have tried to
exhaustively and comprehensively characterize the human genome. Recent advances in …
exhaustively and comprehensively characterize the human genome. Recent advances in …
Novel open reading frames in human accelerated regions and transposable elements reveal new leads to understand schizophrenia and bipolar disorder
C Erady, K Amin, TOAE Onilogbo, J Tomasik… - Molecular …, 2022 - nature.com
Schizophrenia (SCZ) and bipolar disorder are debilitating neuropsychiatric disorders arising
from a combination of environmental and genetic factors. Novel open reading frames …
from a combination of environmental and genetic factors. Novel open reading frames …
Microproteins—Discovery, structure, and function
Advances in proteogenomic technologies have revealed hundreds to thousands of
translated small open reading frames (sORFs) that encode microproteins in genomes across …
translated small open reading frames (sORFs) that encode microproteins in genomes across …