The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

Core histones package the genome into nucleosomes and control its accessibility to
transcription factors. High mobility group proteins (HMGs) are, after histones, the second …

The encounter of elongating RNA polymerase II (RNAPIIo) with DNA lesions has severe
consequences for the cell as this event provides a strong signal for P53-dependent …

Eukaryotic genomes are organized into condensed, heterogeneous chromatin fibers
throughout much of the cell cycle. Here we describe recent studies indicating that even …

Restoration of UV-inhibited transcription requires removal of transcription-blocking DNA
lesions by transcription-coupled repair (TCR). In mammals, TCR is dependent on CSA and …

The high mobility group (HMG) proteins are a superfamily of abundant and ubiquitous
nuclear proteins that bind to DNA and nucleosomes and induce structural changes in the …

Although the three families of mammalian HMG proteins (HMGA, HMGB and HMGN)
participate in many of the same nuclear processes, each family plays its own unique role in …

The eukaryotic genome is packaged into a periodic nucleoprotein structure termed
chromatin. The repeating unit of chromatin, the nucleosome, consists of DNA that is wound …

Introduction: Despite advances in treatment of diabetes mellitus, its prevalence continues to
rise globally. Medications available are unable to control the vascular complications …

The present invention describes compositions and methods showing that the spatial
proximity of intracellular compo nents may be related to their ability to cooperate in intracel …