A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …

Reactive oxygen species (ROS) are subcellular messengers in signal transductions
pathways with both beneficial and deleterious roles. ROS are generated as a by-product of …

Beyond their role as a cellular powerhouse, mitochondria are emerging as integral players
in molecular signaling and cell fate determination through reactive oxygen species (ROS) …

In heart failure, alterations of Na+ and Ca2+ handling, energetic deficit, and oxidative stress
in cardiac myocytes are important pathophysiological hallmarks. Mitochondria are central to …

Vascular disease and heart failure impart an enormous burden in terms of global morbidity
and mortality. Although there are many different causes of cardiac and vascular disease …

The heart has a high rate of ATP production and turnover that is required to maintain its
continuous mechanical work. Perturbations in ATP-generating processes may therefore …

Systolic and diastolic myocardial dysfunction has been demonstrated to be associated with
an activation of the circulating and local renin–angiotensin–aldosterone system (RAAS), and …

The free radical theory of aging proposes that reactive oxygen species (ROS)-induced
accumulation of damage to cellular macromolecules is a primary driving force of aging and a …

Rationale: Despite increasing prevalence and incidence of heart failure (HF), therapeutic
options remain limited. In early stages of HF, sudden cardiac death (SCD) from ventricular …

Aging can be seen as process characterized by accumulation of oxidative stress induced
damage. Oxidative stress derives from different endogenous and exogenous processes, all …