Exposure of cells to high voltage electric pulses increases transiently membrane
permeability through membrane electroporation. Electroporation can be reversible and is …

Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …

Comparative oncology clinical trials play an important and growing role in cancer research
and drug development efforts. These trials, typically conducted in companion (pet) dogs …

Thermal tumor ablation techniques including radiofrequency, microwave, LASER, high-
intensity focused ultrasound and cryoablation are routinely used to treated liver, kidney …

In the dog, primary intracranial neoplasia represents~ 2–5% of all cancers and is especially
common in certain breeds including English and French bulldogs and Boxers. The most …

The blood-brain barrier (BBB) presents a formidable obstacle to the effective delivery of
systemically administered pharmacological agents to the brain, with~ 5% of candidate drugs …

Abstract Non‐thermal, intermediate frequency (100–500 kHz) electrotherapies present a
unique therapeutic strategy to treat malignant neoplasms. Here, pulsed electric fields (PEFs) …

High-frequency bipolar high-voltage pulsed electric field can be used in tumor ablation to
uniform the electric field distribution in the ablated region and inhibit muscle contraction …

This paper describes the operation of a solid-state generator proposed to produce high-
frequency bipolar high-voltage pulse bursts on resistive-type loads, intended for medical …

Glioblastoma (GBM) is the most common and aggressive malignant glioma, treatment of
which has not improved significantly in many years. This is due to the unique challenges that …