Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …

Mitochondria are cellular organelles that orchestrate a vast range of biological processes,
from energy production and metabolism to cell death and inflammation. Despite this …

The dynamic properties of mitochondria—including their fusion, fission, and degradation—
are critical for their optimal function in energy generation. The interplay of fusion and fission …

Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

Mitochondria are highly dynamic organelles undergoing coordinated cycles of fission and
fusion, referred as 'mitochondrial dynamics', in order to maintain their shape, distribution and …

Mitochondria sense and respond to many stressors and can support cell survival or death
through energy production and signalling pathways. Mitochondrial responses depend on …

The mitochondria is the major hub to convert energy for cellular processes. Dysregulation of
mitochondrial function is one of the classical hallmarks of aging, and mitochondrial …

Mitochondria serve as a hub for a multitude of vital cellular processes. To ensure an efficient
deployment of mitochondrial tasks, organelle homeostasis needs to be preserved …

Mitochondrial dysfunction occurs during aging, but its impact on tissue senescence is
unknown. Here, we find that sedentary but not active humans display an age-related decline …

Mitochondrial dynamics are regulated by two sets of opposed processes: mitochondrial
fusion and fission, and mitochondrial biogenesis and degradation (including mitophagy), as …