The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …

Adipose tissue plays a significant role in whole body energy homeostasis. Obesity‐
associated diabetes, fatty liver and metabolic syndrome are closely linked to adipose stress …

The bulk structure of biological membranes consists of a bilayer of amphipathic lipids.
According to the fluid mosaic model proposed by Singer and Nicholson, the …

Statins are the gold-standard treatment for the prevention of primary and secondary
cardiovascular disease, which is the leading cause of mortality worldwide. Despite the safety …

Alzheimer's disease (AD) is a risk factor for type 2 diabetes and vice versa, and a growing
body of evidence indicates that these diseases are connected both at epidemiological …

Insulin-resistance is a characteristic feature of type 2 diabetes (T2D) and plays a major role
in the pathogenesis of this disease. Skeletal muscles are quantitatively the biggest glucose …

Diabetes contributes to about 30% morbidity and mortality world-wide and has tidal wave
increases in several countries in Asia. Diabetes is a multi-factorial disease compounded by …

Gangliosides, the glycosphingolipids carrying one or several sialic acid residues, are
located on the outer leaflet of the plasma membrane in glycolipid-enriched microdomains …

Recent evidence suggests that Alzheimer's disease (AD) is closely linked with insulin
resistance, as seen in type 2 diabetes mellitus (T2DM). Insulin signaling is impaired in AD …

Gangliosides constitute a large family of sialic acid-containing glycosphingolipids which play
a key regulatory role in a diverse array of cellular processes, including receptor-associated …