Most histones are assembled into nucleosomes behind the replication fork to package newly
synthesized DNA. By contrast, histone variants, which are encoded by separate genes, are …

Recent genome sequencing efforts in a variety of cancers have revealed mutations and/or
structural alterations in ATRX and DAXX, which together encode a complex that deposits …

Human glial progenitor cells (hGPCs) exhibit diminished expansion competence with age,
as well as after recurrent demyelination. Using RNA-sequencing to compare the gene …

Introduction: ATRX is a chromatin remodeling protein whose main function is the deposition
of the histone variant H3. 3. ATRX mutations are widely distributed in glioma, and correlate …

Nearly half of the human genome consists of endogenous retroelements (EREs) and their
genetic remnants, a small fraction of which carry the potential to propagate in the host …

ATRX, a chromatin remodeler protein, is recurrently mutated in H3F3A-mutant pediatric
glioblastoma (GBM) and isocitrate dehydrogenase (IDH)-mutant grade 2/3 adult glioma …

Gene silencing by heterochromatin plays a crucial role in cell identity. Here, we characterize
the localization, the biogenesis, and the function of an atypical heterochromatin, which is …

In recent years, significant advances have been made in understanding the intricate details
of the mechanisms underlying alternative lengthening of telomeres (ALT). Studies of a …

ATRX is a chromatin remodelling factor found at a wide range of tandemly repeated
sequences including telomeres (TTAGGG) n. ATRX mutations are found in nearly all …

Transcription factors (TFs) are proteins that affect gene expression by binding to regulatory
regions of DNA in a sequence specific manner. The binding of TFs to DNA is controlled by …