CD44, a complex transmembrane glycoprotein, exists in multiple molecular forms, including
the standard isoform CD44s and CD44 variant isoforms. CD44 participates in multiple …

CD44, a non-kinase transmembrane glycoprotein, is overexpressed in several cell types
including cancer stem cells and frequently shows alternative spliced variants that are …

CD44 is a cell surface adhesion receptor that is highly expressed in many cancers and
regulates metastasis via recruitment of CD44 to the cell surface. Its interaction with …

The predominant type of immune cell in the brain is the microglia, a type of tissue-resident
macrophage. In a variety of neurodegenerative settings, microglia alter their transcriptional …

Osteopontin (OPN) also known by its official gene designation secreted phosphoprotein‐1
(SPP1) is a fascinating, multifunctional protein expressed in a number of cell types that …

Blood–brain barrier (BBB) dysfunction, characterized by degradation of BBB junctional
proteins and increased permeability, is a crucial pathophysiological feature of acute …

CD44 is a cell adhesion molecule that plays an important role in tumor progression and
metastasis. The role of CD44 in tumorigenesis is due to its binding to extracellular matrix …

The concept of a matricellular protein was first proposed by Paul Bornstein in the mid-1990s
to account for the non-lethal phenotypes of mice with inactivated genes encoding …

Urinary stone disease is an ailment that has afflicted human kind for many centuries.
Nephrolithiasis is a significant clinical problem in everyday practice with a subsequent …

Inflammatory cytokines are necessary for an acute response to injury and the progressive
healing process. However, when this acute response does not resolve and becomes …