Variance between studies in a meta-analysis will exist. This heterogeneity may be of clinical,
methodological or statistical origin. The last of these is quantified by the I 2-statistic. We …

Purpose To identify, describe and discuss the parameters used to predict weaning from
mechanical ventilation and extubation outcomes. Methods Systematic review of scientific …

Background Current management practices and outcomes in weaning from invasive
mechanical ventilation are poorly understood. We aimed to describe the epidemiology …

Rationale: The weaning process concerns all patients receiving mechanical ventilation. A
previous classification into simple, prolonged, and difficult weaning ignored weaning failure …

Background The British Thoracic Society (BTS) published the guideline,'The use of non-
invasive ventilation in acute respiratory failure', in 2002. 1 This was in response to trials …

Introduction Small-study effects refer to the fact that trials with limited sample sizes are more
likely to report larger beneficial effects than large trials. However, this has never been …

Respiratory complications after tracheal extubation are associated with significant morbidity
and mortality, suggesting that process improvements in this clinical area are needed. The …

Ventilator-associated pneumonia is an important healthcare-associated infection.
Interventions for the prevention of ventilator-associated pneumonia are often used within …

Introduction The number of patients requiring prolonged mechanical ventilation (PMV) is
likely to increase. Transferring patients to specialised weaning units may improve outcomes …

Managing healthcare demand and capacity is especially difficult in the context of the COVID-
19 pandemic, where limited intensive care resources can be overwhelmed by a large …