Abstract C2H2 zinc-finger (ZF) proteins form the largest family of DNA-binding transcription
factors coded by mammalian genomes. In a typical DNA-binding ZF module, there are …

Severe speech disorders lead to poor literacy, reduced academic attainment and negative
psychosocial outcomes. As early as the 1950s, the familial nature of speech disorders was …

Objective Determining the genetic basis of speech disorders provides insight into the
neurobiology of human communication. Despite intensive investigation over the past 2 …

FOXP2-related speech and language disorder (FOXP2-SLD) is caused by heterozygous
FOXP2 pathogenic variants (including whole-or partial-gene deletions). The core phenotype …

Helios, a member of the Ikaros family of transcription factors, is predominantly expressed in
develo** thymocytes, activated T cells, and regulatory T cells (Tregs). Studies in mice …

Objective Despite the strong genetic component of frontotemporal dementia (FTD), a
substantial proportion of patients remain genetically unresolved. We performed an in-depth …

The multidimensional nature of obsessive-compulsive disorder (OCD) has been consistently
reported. Clinical and biological characteristics have been associated with OCD dimensions …

Biallelic variants of the gene encoding for the zinc‐finger protein 142 (ZNF142) have
recently been associated with intellectual disability (ID), speech impairment, seizures, and …

The ZNF142 gene on chromosome 2q35 contains ten exons and encodes a zinc finger
protein 142 with 31 C2H2-type zinc fingers domain. Pathogenic variants in ZNF142 result in …

Background Sex-specific predilection in neurological diseases caused by mutations in
autosomal genes is a phenomenon whose molecular basis is poorly understood. We …