Mitochondrial fusion: the machineries in and out
S Gao, J Hu - Trends in cell biology, 2021 - cell.com
Mitochondria are highly dynamic organelles that constantly undergo fission and fusion.
Disruption of mitochondrial dynamics undermines their function and causes several human …
Disruption of mitochondrial dynamics undermines their function and causes several human …
Mitochondrial dynamics in mammalian health and disease
The meaning of the word mitochondrion (from the Greek mitos, meaning thread, and
chondros, grain) illustrates that the heterogeneity of mitochondrial morphology has been …
chondros, grain) illustrates that the heterogeneity of mitochondrial morphology has been …
Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy
C Delettre, G Lenaers, JM Griffoin, N Gigarel… - Nature …, 2000 - nature.com
Abstract Optic atrophy type 1 (OPA1, MIM 165500) is a dominantly inherited optic
neuropathy occurring in 1 in 50,000 individuals 1, 2, 3 that features progressive loss in …
neuropathy occurring in 1 in 50,000 individuals 1, 2, 3 that features progressive loss in …
OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28
C Alexander, M Votruba, UEA Pesch, DL Thiselton… - Nature …, 2000 - nature.com
Autosomal dominant optic atrophy (ADOA) is the most prevalent hereditary optic neuropathy
resulting in progressive loss of visual acuity, centrocoecal scotoma and bilateral temporal …
resulting in progressive loss of visual acuity, centrocoecal scotoma and bilateral temporal …
Mitochondrial dysfunction as a cause of optic neuropathies
Mitochondria are increasingly recognized as central players in the life and death of cells and
especially of neurons. The energy-dependence of retinal ganglion cells (RGC) and their …
especially of neurons. The energy-dependence of retinal ganglion cells (RGC) and their …
Mitochondrial fission and fusion: molecular mechanisms, biological functions, and related disorders
Mitochondria are dynamic organelles that undergo fusion and fission. These active
processes occur continuously and simultaneously and are mediated by nuclear-DNA …
processes occur continuously and simultaneously and are mediated by nuclear-DNA …
Mutation spectrum and splicing variants in the OPA1 gene
C Delettre, JM Griffoin, J Kaplan, H Dollfus, B Lorenz… - Human genetics, 2001 - Springer
Optic atrophy type 1 (OPA1, MIM 165500) is a dominantly inherited optic neuropathy that
features low visual acuity leading in many cases to legal blindness. We have recently …
features low visual acuity leading in many cases to legal blindness. We have recently …
Dominant optic atrophy: Culprit mitochondria in the optic nerve
Dominant optic atrophy (DOA) is an inherited mitochondrial disease leading to specific
degeneration of retinal ganglion cells (RGCs), thus compromising transmission of visual …
degeneration of retinal ganglion cells (RGCs), thus compromising transmission of visual …
Dominant optic atrophy
G Lenaers, C Hamel, C Delettre… - Orphanet journal of rare …, 2012 - Springer
Definition of the disease Dominant Optic Atrophy (DOA) is a neuro-ophthalmic condition
characterized by a bilateral degeneration of the optic nerves, causing insidious visual loss …
characterized by a bilateral degeneration of the optic nerves, causing insidious visual loss …
Oxidative stress in optic neuropathies
B Sanz-Morello, H Ahmadi, R Vohra, S Saruhanian… - Antioxidants, 2021 - mdpi.com
Increasing evidence indicates that changes in the redox system may contribute to the
pathogenesis of multiple optic neuropathies. Optic neuropathies are characterized by the …
pathogenesis of multiple optic neuropathies. Optic neuropathies are characterized by the …