Methylene-and alkylidenecyclopropanes (MCPs and ACPs, 1, Figure 1) and-cyclobutanes
(MCBs and ACBs, 2, Figure 1) are highly strained molecules, but at the same time most of …

Elevated circulating glucose level due to β-cell dysfunction has been a key marker of Type-II
diabetes. Glycogen synthase kinase-3 (GSK-3) has been recognized as an enzyme involved …

The trend toward designing large hydrophobic molecules for lead optimization is often
associated with poor drug-likeness and high attrition rates in drug discovery and …

Objective Kinase hyperactivity occurs in both neurodegenerative disease and cancer.
Lesions containing hyperphosphorylated aggregated TDP‐43 characterize amyotrophic …

Abstract Glycogen synthase kinase-3 (GSK-3) has been proposed to play a crucial role in
the pathogenesis of many diseases including cancer, stroke, bipolar disorders, diabetes and …

The pyrimidine scaffold represents one of the privileged structures in chemistry, and there
has been an increase in number of studies utilizing this scaffold and its derivatives. The …

CDC7 is a serine/threonine kinase that has been shown to be required for the initiation and
maintenance of DNA replication. Up-regulation of CDC7 is detected in multiple tumor cell …

The initiation reactions of DNA synthesis are central processes during human chromosomal
DNA replication. They are separated into two main processes: the initiation events at …

Catalytic reaction of arylhydroxamic acids with alkenes represents a convenient method for
preparation of biologically active dihydroisoquinolones. Here, the rhodium (III) complex …

Cdc7 serine/threonine kinase is a key regulator of DNA synthesis in eukaryotic organisms.
Cdc7 inhibition through si RNA or prototype small molecules causes p53 independent …