Beyond the margins: real-time detection of cancer using targeted fluorophores

RR Zhang, AB Schroeder, JJ Grudzinski… - Nature reviews Clinical …, 2017 - nature.com
Over the past two decades, synergistic innovations in imaging technology have resulted in a
revolution in which a range of biomedical applications are now benefiting from fluorescence …

Primary brain tumours in adults

D Ricard, A Idbaih, F Ducray, M Lahutte… - The Lancet, 2012 - thelancet.com
Important advances have been made in the understanding and management of adult
gliomas and primary CNS lymphomas—the two most common primary brain tumours …

Interactive effects of molecular, therapeutic, and patient factors on outcome of diffuse low-grade glioma

SL Hervey-Jumper, Y Zhang, JJ Phillips… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE In patients with diffuse low-grade glioma (LGG), the extent of surgical tumor
resection (EOR) has a controversial role, in part because a randomized clinical trial with …

Central nervous system cancers, version 3.2020, NCCN clinical practice guidelines in oncology

LB Nabors, J Portnow, M Ahluwalia, J Baehring… - Journal of the National …, 2020 - jnccn.org
The NCCN Guidelines for Central Nervous System (CNS) Cancers focus on management of
adult CNS cancers ranging from noninvasive and surgically curable pilocytic astrocytomas …

The impact of surgery in molecularly defined low-grade glioma: an integrated clinical, radiological, and molecular analysis

MMJ Wijnenga, PJ French, HJ Dubbink… - Neuro …, 2018 - academic.oup.com
Background Extensive resections in low-grade glioma (LGG) are associated with improved
overall survival (OS). However, World Health Organization (WHO) classification of gliomas …

Intraoperative brain cancer detection with Raman spectroscopy in humans

M Jermyn, K Mok, J Mercier, J Desroches… - Science translational …, 2015 - science.org
Cancers are often impossible to visually distinguish from normal tissue. This is critical for
brain cancer where residual invasive cancer cells frequently remain after surgery, leading to …

Comparison of a strategy favoring early surgical resection vs a strategy favoring watchful waiting in low-grade gliomas

AS Jakola, KS Myrmel, R Kloster, SH Torp, S Lindal… - Jama, 2012 - jamanetwork.com
Context There are no controlled studies on surgical treatment of diffuse low-grade gliomas
(LGGs), and management is controversial. Objective To examine survival in population …

Spontaneous and therapeutic prognostic factors in adult hemispheric World Health Organization Grade II gliomas: a series of 1097 cases

L Capelle, D Fontaine, E Mandonnet… - Journal of …, 2013 - thejns.org
Object The spontaneous prognostic factors and optimal therapeutic strategy for WHO Grade
II gliomas (GIIGs) have yet to be unanimously defined. Specifically, the role of resection is …

Primary brain tumors in adults: diagnosis and treatment

A Perkins, G Liu - American family physician, 2016 - aafp.org
Primary intracranial tumors of the brain structures, including meninges, are rare with an
overall five-year survival rate of 33.4%; they are collectively called primary brain tumors …

Long-term outcomes after supratotal resection of diffuse low-grade gliomas: a consecutive series with 11-year follow-up

H Duffau - Acta neurochirurgica, 2016 - Springer
Background Total or subtotal surgical resection of WHO grade II glioma (diffuse low-grade
glioma, DLGG) can significantly increase survival. Moreover, a supratotal resection, ie, an …