Abstract In 1972 the Fluid—Mosaic Membrane Model of membrane structure was proposed
based on thermodynamic principals of organization of membrane lipids and proteins and …

Cell membranes are composed of a lipid bilayer, containing proteins that span the bilayer
and/or interact with the lipids on either side of the two leaflets. Although recent advances in …

Cell membranes display a tremendous complexity of lipids and proteins designed to perform
the functions cells require. To coordinate these functions, the membrane is able to laterally …

Lipid composition determines membrane properties, and cholesterol plays a major role in
this determination as it regulates membrane fluidity and permeability, as well as induces the …

A new aspect of cell membrane structure is presented, based on the dynamic clustering of
sphingolipids and cholesterol to form rafts that move within the fluid bilayer. It is proposed …

Whereas some rare lipids contribute to the identity of cell organelles, we focus on the
abundant lipids that form the matrix of organelle membranes. Observations using bioprobes …

Although lipids are biomolecules with seemingly simple chemical structures, the molecular
composition of the cellular lipidome is complex and, currently, poorly understood. The exact …

▪ Abstract Recent studies showing that detergent-resistant membrane fragments can be
isolated from cells suggest that biological membranes are not always in a liquid-crystalline …

Sterols, which are isoprenoid derivatives, are structural components of biological
membranes. Special attention is now being given not only to their structure and function, but …

▪ Abstract Views of how cell membranes are organized are presently changing. The lipid
bilayer that constitutes these membranes is no longer understood to be a homogeneous …