Poorly water-soluble drugs continue to be a problematic, yet important class of
pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in …

A layer of mucus covers the surface of all wet epithelia throughout the human body. Mucus is
a hydrogel mainly composed of water, mucins (glycoproteins), DNA, proteins, lipids, and cell …

Mucus is a viscoelastic and adhesive gel that protects the lung airways, gastrointestinal (GI)
tract, vagina, eye and other mucosal surfaces. Most foreign particulates, including …

Viscoelastic mucus lines all mucosal surfaces of the body and forms a potential barrier to
mucosal drug delivery. Mucus is mainly composed of water and mucins; high molecular …

Secretion of bicarbonate into the adherent layer of mucus gel creates a pH gradient with a
near-neutral pH at the epithelial surfaces in stomach and duodenum, providing the first line …

To determine whether or not large macromolecules and viruses can diffuse through mucus,
we observed the motion of proteins, microspheres, and viruses in fresh samples of human …

The mucosa of the gastrointestinal tract, eyes, nose, lungs, cervix and vagina is lined by
epithelium interspersed with mucus-secreting goblet cells, all of which contribute to their …

Mucus is a complex hydrogel, comprising glycoproteins, lipids, salts, DNA, enzymes and
cellular debris, covering many epithelial surfaces in the human body. Once secreted, mucin …

Mucus, the slimy, viscous secretion that covers epithelial surfaces throughout the body,
contains water, salts, immunoglobulins, secreted proteins, and mucin. Mucus ecretions are …

The mucosal immune system actively transports large quantities of antibodies into all mucus
secretions, and these secreted antibodies help prevent infectious entry of many pathogens …