The transition model of RTK activation: A quantitative framework for understanding RTK signaling and RTK modulator activity
Here, we discuss the transition model of receptor tyrosine kinase (RTK) activation, which is
derived from biophysical investigations of RTK interactions and signaling. The model …
derived from biophysical investigations of RTK interactions and signaling. The model …
Protein homodimer sequestration with small molecules: Focus on PD-L1
C Bailly, G Vergoten - Biochemical Pharmacology, 2020 - Elsevier
Monoclonal antibodies targeting the PD-1/PD-L1 immune checkpoint have emerged as
efficient cancer biotherapeutics. In parallel, small molecules targeting PD-L1 are actively …
efficient cancer biotherapeutics. In parallel, small molecules targeting PD-L1 are actively …
EGFR forms ligand-independent oligomers that are distinct from the active state
The human epidermal growth factor receptor (EGFR/ERBB1) is a receptor tyrosine kinase
(RTK) that forms activated oligomers in response to ligand. Much evidence indicates that …
(RTK) that forms activated oligomers in response to ligand. Much evidence indicates that …
[HTML][HTML] P120 catenin potentiates constitutive E-cadherin dimerization at the plasma membrane and regulates trans binding
Cadherins are essential adhesion proteins that regulate tissue cohesion and paracellular
permeability by assembling dense adhesion plaques at cell-to-cell contacts. Adherens …
permeability by assembling dense adhesion plaques at cell-to-cell contacts. Adherens …
Quantifying the strength of heterointeractions among receptor tyrosine kinases from different subfamilies: Implications for cell signaling
Receptor tyrosine kinases (RTKs) are single-pass membrane proteins that control vital cell
processes such as cell growth, survival, and differentiation. There is a growing body of …
processes such as cell growth, survival, and differentiation. There is a growing body of …
Digital nanoreactors to control absolute stoichiometry and spatiotemporal behavior of DNA receptors within lipid bilayers
Interactions between membrane proteins are essential for cell survival but are often poorly
understood. Even the biologically functional ratio of components within a multi-subunit …
understood. Even the biologically functional ratio of components within a multi-subunit …
A Bilayer Polyurethane Patch with Sustained Growth Factor Release and Antibacteria for Re-epithelization of Large-Scale Oral Mucosal Defects
Q Zhang, J Chen, T Zhang, D Liu, X Long… - … Applied Materials & …, 2024 - ACS Publications
In the field of oral and maxillofacial surgery, extensive oral soft-tissue injuries occur
repeatedly in clinical practice; however, effective restorative materials are lacking. In this …
repeatedly in clinical practice; however, effective restorative materials are lacking. In this …
The biased ligands NGF and NT-3 differentially stabilize Trk-A dimers
Trk-A is a receptor tyrosine kinase (RTK) that plays an essential role in the development and
functioning of the nervous system. Trk-A is expressed in neurons and signals in response to …
functioning of the nervous system. Trk-A is expressed in neurons and signals in response to …
Probing Membrane Protein Association Using Concentration‐Dependent Number and Brightness
We introduce concentration‐dependent number and brightness (cdN&B), a fluorescence
fluctuation technique that can be implemented on a standard confocal microscope and can …
fluctuation technique that can be implemented on a standard confocal microscope and can …
Engineering aptamers to enhance their interaction with protein target for selective inhibition of cell surface receptors
L Song, Y Wang, Y Guo, S Bulale, M Zhou, F Yu… - International Journal of …, 2024 - Elsevier
Cell surface receptors play a key role in intracellular signaling, and their overexpression and
activation are among the drivers of multiple diseases. Selective inhibition of cell surface …
activation are among the drivers of multiple diseases. Selective inhibition of cell surface …