The extracellular matrix (ECM) is critical to biological architecture and determines cellular
properties, function and activity. In many situations it is highly abundant, with collagens and …

Mammalian heme peroxidases are fascinating due to their unique peculiarity of oxidizing
(pseudo) halides under physiologically relevant conditions. These proteins are able either to …

Cardiovascular disease is the leading cause of death, with atherosclerosis the major
underlying cause. While often asymptomatic for decades, atherosclerotic plaque …

Basement membranes are specialized extracellular matrices that underlie arterial wall
endothelial cells, with laminin being a key structural and biologically-active component …

Cardiovascular disease is the leading cause of morbidity and mortality in the Western and
develo** world, and the incidence of cardiovascular disease is increasing with the longer …

Perivascular spaces play a pivotal role in the exchange between cerebrospinal and
interstitial fluids, and in the clearance of waste in the CNS, yet their precise anatomical …

Matrix metalloproteinase-9 (MMP9, gelatinase B) plays a key role in the degradation of
extracellular-matrix (ECM) proteins in both normal physiology and multiple pathologies …

Activated white blood cells generate multiple oxidants in response to invading pathogens.
Thus, hypochlorous acid (HOCl) is generated via the reaction of myeloperoxidase (from …

Perlecan, or heparan sulfate proteoglycan 2 (HSPG2), is a ubiquitous heparan sulfate
proteoglycan that has major roles in tissue and organ development and wound healing by …

Fibronectin (FN) occurs as both a soluble form, in plasma and at sites of tissue injury, and a
cellular form in tissue extracellular matrices (ECM). FN is critical to wound repair, ECM …