Multiple sclerosis (MS) is the most frequent, demyelinating disease of the central nervous
system (CNS) in Northern Europeans and North Americans. Despite intensive research its …

The kynurenine pathway (KP) is the major metabolic pathway of the essential amino acid
tryptophan (TRP). Stimulation by inflammatory molecules, such as interferon-γ (IFN-γ), is the …

In addition to the major population of infiltrating leukocytes recovered from inflamed rat
central nervous system (CNS), all of which expressed high levels of leukocyte common …

Background There is consensus that experimental autoimmune encephalomyelitis (EAE)
can be mediated by myelin specific T cells of Th1 as well as of Th17 phenotype, but the …

During inflammatory conditions in the central nervous system (CNS), immune cells
immigrate into the CNS and can be detected in the CNS parenchyma and in the …

Mice lacking in CD8 were generated from homologous recombination in embryonal stem
cells at the CD8 locus and bred with the experimental allergic encephalomyelitis (EAE) …

Diseases of the central nervous system (CNS) are often associated with vascular
disturbances or inflammation and frequently both. Consequently, endothelial cells and …

The central nervous system (CNS) is an immunologically specialized organ. The blood-brain
barrier regulates the passage of molecules and cells into the CNS. Robust immune …

The central nervous system (CNS) is considered to be an immunological privileged site.
However, inflammatory reactions in response to virus infections, in multiple sclerosis (MS) …

Whereas carcinogenesis requires the acquisition of driver mutations in progenitor cells,
tumor growth and progression are heavily influenced by the local microenvironment …