Aging is the greatest risk factor for chronic human diseases, including many eye diseases.
Geroscience aims to understand the effects of the aging process on these diseases …

Despite being a treatable disease, cataract is still the leading cause for blindness in the
world. Solar ultraviolet radiation is epidemiologically linked to cataract development, while …

Integrins are a family of heterodimeric transmembrane receptors that mediate adhesion to
the extracellular matrix (ECM). In addition to their role as adhesion receptors, integrins can …

Periodontal disease is a prevalent chronic inflammatory condition characterised by an
aberrant host response to a pathogenic plaque biofilm resulting in local tissue damage and …

Age-related cataract (ARC) is the most common cause of severe visual impairment and
blindness. The precise mechanisms of ARC are not completely understood, but it is well …

Background Stress responses within the β cell have been linked with both increased β cell
death and accelerated immune activation in type 1 diabetes (T1D). At present, information …

Background Germline mutations in heat shock factor 4 (HSF4) cause congenital cataracts.
Previously, we have shown that HSF4 is involved in regulating lysosomal pH in mouse lens …

Purpose: To determine the impact of the loss of syndecan 1 (SDC1) on intraepithelial
corneal nerves (ICNs) during homeostasis, aging, and in response to 1.5-mm trephine and …

Photoaging is unique to the skin and is accompanied by an increased risk of tumors. To
explore the transcriptomic regulatory mechanism of skin photoaging, the epidermis, and …

Effective and efficient efferocytosis of dead cells and associated cellular debris are critical to
tissue homeostasis and healing of injured tissues. This important task was previously …