From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy

T Efferth - Seminars in cancer biology, 2017 - Elsevier
Artemisia annua L. is used throughout Asia and Africa as tea and press juice to treat malaria
and related symptomes (fever, chills). Its active ingredient, artemisinin (ARS), has been …

Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action

YK Wong, C Xu, KA Kalesh, Y He, Q Lin… - Medicinal research …, 2017 - Wiley Online Library
Artemisinin and its derivatives (collectively termed as artemisinins) are among the most
important and effective antimalarial drugs, with proven safety and efficacy in clinical use …

Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

J Wang, CJ Zhang, WN Chia, CCY Loh, Z Li… - Nature …, 2015 - nature.com
The mechanism of action of artemisinin and its derivatives, the most potent of the anti-
malarial drugs, is not completely understood. Here we present an unbiased chemical …

Recent advances in sonodynamic therapy by MOFs-based platforms for biomedical applications

W Hu, S Wang, C Jiang, M Zheng, Z Bai, D Srivastava… - Dyes and …, 2023 - Elsevier
Sonodynamic therapy (SDT) is a new treatment method combining low-intensity ultrasound
with sono-sensitizers, which has the advantages of non-invasiveness as well as low side …

[HTML][HTML] Artemisinin, the magic drug discovered from traditional Chinese medicine

J Wang, C Xu, YK Wong, Y Li, F Liao, T Jiang, Y Tu - Engineering, 2019 - Elsevier
Artemisinin and its derivatives represent the most important and influential class of drugs in
the fight against malaria. Since the discovery of artemisinin in the early 1970s, the global …

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

N Klonis, MP Crespo-Ortiz, I Bottova… - Proceedings of the …, 2011 - pnas.org
Combination regimens that include artemisinin derivatives are recommended as first line
antimalarials in most countries where malaria is endemic. However, the mechanism of …

Antitumor activity of artemisinin and its derivatives: from a well‐known antimalarial agent to a potential anticancer drug

MP Crespo-Ortiz, MQ Wei - BioMed Research International, 2012 - Wiley Online Library
Improvement of quality of life and survival of cancer patients will be greatly enhanced by the
development of highly effective drugs to selectively kill malignant cells. Artemisinin and its …

Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7

HM Ismail, V Barton, M Phanchana… - Proceedings of the …, 2016 - pnas.org
The artemisinin (ART)-based antimalarials have contributed significantly to reducing global
malaria deaths over the past decade, but we still do not know how they kill parasites. To gain …

Traditional medicines and globalization: current and future perspectives in ethnopharmacology

M Leonti, L Casu - Frontiers in pharmacology, 2013 - frontiersin.org
The ethnopharmacological approach toward the understanding and appraisal of traditional
and herbal medicines is characterized by the inclusions of the social as well as the natural …

Anti-cancer natural products isolated from chinese medicinal herbs

W Tan, J Lu, M Huang, Y Li, M Chen, G Wu, J Gong… - Chinese medicine, 2011 - Springer
In recent years, a number of natural products isolated from Chinese herbs have been found
to inhibit proliferation, induce apoptosis, suppress angiogenesis, retard metastasis and …