Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …

Viral replication is a process that involves an extremely high turnover of cellular molecules.
Since viruses depend on the host cell to obtain the macromolecules needed for their proper …

Viruses are obligate intracellular parasites that make use of the host metabolic machineries
to meet their biosynthetic needs. Thus, identifying the host pathways essential for the virus …

The pathogenesis of SARS-CoV-2 remains to be completely understood, and detailed SARS-
CoV-2 cellular cytopathic effects requires definition. We performed a comparative …

Flaviviruses are emerging arthropod-borne pathogens that cause life-threatening diseases
such as yellow fever, dengue, West Nile encephalitis, tick-borne encephalitis, Kyasanur …

Dengue is the most common mosquito-borne viral disease in humans. Changes of lipid-
related metabolites in endoplasmic reticulum of dengue virus (DENV) infected cells have …

Viruses subvert the functions of their host cells to replicate and form new viral progeny. The
endoplasmic reticulum (ER) has been identified as a central organelle that governs the …

Hepatitis C infection is the leading cause of liver diseases worldwide and a major health
concern that affects an estimated 3% of the global population. Novel therapies available …

Zika virus (ZIKV) infection is a global public health concern linked to adult neurological
disorders and congenital diseases in newborns. Host lipid metabolism, including lipid …

In a previous study, twelve antimalarial compounds, amodiaquine (AQ) and derivatives,
were shown to have potent anti-dengue viral (DENV) activity by using the stable DENV2 …