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Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs
Abstract According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …
Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for type II diabetes
The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
Iron and Alzheimer's disease: from pathogenesis to therapeutic implications
JL Liu, YG Fan, ZS Yang, ZY Wang… - Frontiers in neuroscience, 2018 - frontiersin.org
As people age, iron deposits in different areas of the brain may impair normal cognitive
function and behavior. Abnormal iron metabolism generates hydroxyl radicals through the …
function and behavior. Abnormal iron metabolism generates hydroxyl radicals through the …
Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems
JM Lü, PH Lin, Q Yao, C Chen - Journal of cellular and …, 2010 - Wiley Online Library
Introduction• Free radical scavenging‐Scavenging superoxide and other ROS‐Scavenging
hydroxyl radical and other ROS‐Stable radical scavenging• Metal ion (Fe2+, Fe3+, Cu2+ …
hydroxyl radical and other ROS‐Stable radical scavenging• Metal ion (Fe2+, Fe3+, Cu2+ …
Nanoparticles in cellular drug delivery
This review highlights the properties of nanoparticles used in targeted drug delivery,
including delivery to cells as well as organelle targets, some of the known pharmacokinetic …
including delivery to cells as well as organelle targets, some of the known pharmacokinetic …
The metallobiology of Alzheimer's disease
AI Bush - Trends in neurosciences, 2003 - cell.com
The cause of Alzheimer's disease (AD) is closely related to the aggregation of a normal
protein, β-amyloid (Aβ), within the neocortex. Recently, evidence has been gathered to …
protein, β-amyloid (Aβ), within the neocortex. Recently, evidence has been gathered to …
Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer's disease
G Bartzokis - Neurobiology of aging, 2004 - Elsevier
A hypothetical model of Alzheimer's disease (AD) as a uniquely human brain disorder
rooted in its exceptional process of myelination is presented. Cortical regions with the most …
rooted in its exceptional process of myelination is presented. Cortical regions with the most …
Recent advancement in therapeutic strategies for Alzheimer's disease: Insights from clinical trials
Alzheimer's disease (AD) is the most prevalent form of dementia, characterized by the
presence of plaques of amyloid beta and Tau proteins. There is currently no permanent cure …
presence of plaques of amyloid beta and Tau proteins. There is currently no permanent cure …
Therapeutic potential and main methods of obtaining selenium nanoparticles
EG Varlamova, EA Turovsky, EV Blinova - International journal of …, 2021 - mdpi.com
This review presents the latest data on the importance of selenium nanoparticles in human
health, their use in medicine, and the main known methods of their production by various …
health, their use in medicine, and the main known methods of their production by various …
[HTML][HTML] The redox chemistry of the Alzheimer's disease amyloid β peptide
There is a growing body of evidence to support a role for oxidative stress in Alzheimer's
disease (AD), with increased levels of lipid peroxidation, DNA and protein oxidation …
disease (AD), with increased levels of lipid peroxidation, DNA and protein oxidation …