All malignant cancers, whether inherited or sporadic, are fundamentally governed by
Darwinian dynamics. The process of carcinogenesis requires genetic instability and highly …

Tyrosine kinases are important cellular signaling proteins that have a variety of biological
activities including cell proliferation and migration. Multiple kinases are involved in …

This Timeline article charts progress in mathematical modelling of cancer over the past 50
years, highlighting the different theoretical approaches that have been used to dissect the …

Background Multicomponent therapeutics offer bright prospects for the control of complex
diseases in a synergistic manner. However, finding ways to screen the synergistic …

Reverse phase protein array (RPPA) technology introduced a miniaturized “antigen-down”
or “dot-blot” immunoassay suitable for quantifying the relative, semi-quantitative or …

The approaches to quantitatively assessing the health risks of chemical exposure have not
changed appreciably in the past 50 to 80 years, the focus remaining on high-dose studies …

Objective Intraamniotic inflammation/infection is the only mechanism of disease with
persuasive evidence of causality for spontaneous preterm labor/delivery. Previous studies …

Glioblastoma multiforme (GBM) is the most aggressive brain tumor that, by virtue of its
resistance to chemotherapy and radiotherapy, is currently incurable. Identification of …

Drug combinations may exhibit synergistic or antagonistic effects. Rational design of
synergistic drug combinations remains a challenge despite active experimental and …

Multiple molecular, cellular, micro-environmental and systemic causes of anticancer drug
resistance have been identified during the last 25 years. At the same time, genome-wide …